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Main description:
Upon completion of the human genome project over 800 G protein-coupled receptor 1 (GPCR) genes, subdivided into five categories, were identified. These receptors sense a diverse array of stimuli, including peptides, ions, lipid analogues, light and odour, in a discriminating fashion. Subsequently, they transduce a signal from the ligand-receptor complex into numerous cellular responses. The importance of GPCRs is further reflected in the fact that they constitute the most common target for therapeutic drugs across a 2 wide range of human disorders. Phylogenetic analysis of GPCRs produced the GRAFS classification system, which subdivides GPCRs into five discrete families: glutamate, rhodopsin, adhesion, frizzled/taste2 and secretin receptors. The adhesion-GPCR family 2 can be further subdivided into eight groups. The field of adhesion-GPCR biology has indeed become large enough to require a volume dedicated solely to this field. The contributors to this book have made a courageous effort to address the key concepts of adhesion-GPCR biology, including the evolution and biochemistry of adhesion-GPCRs; there are extensive discussions on the functional nature of these receptors during development, the immune response and tumourgenesis. Finally, there are chapters dedicated to adhesion-GPCR signalling, an area of intense investigation.
Contents:
THE ADHESION GPCRs; GENE REPERTOI RE, PHYLOGENY AND EVOLUTION.- 7tm?CADHERINS: Developmental Roles and Future Challenges.- LATROPHILIN SIGNALLING IN TISUE POLARITY AND MORPHOGENESIS.- GPS Proteolytic Cleavage of Adhesion?GPCRs.- THE LATROPHILINS, "SPLIT?PERSONALITY" RECEPTORS.- Studies on the Very Large G Protein?Coupled Receptor: From Initial Discovery to Determining Its Role in Sensorineural Deafness in Higher Animals.- Adhesion?GPCRs in the CNS.- GPR56 Interacts withExtracellular Matrix and Regulates Cancer Progression.- Adhesion?GPCRs in Tumorigenesis.- Immunity and adhesion?GPCRs.- CD97 IN LEUKOCYTE TRAFFICKING.- THE ROLE OF CD97 IN REGULATING ADAPTIVE T?CEL RESPONSES.- F4/80: The Macrophage?Specific Adhesion?GPCR and Its Role in Immunoregulation.- Signal transduction mediated through adhesion?GPCRs.- EMERGING ROLES OF BRAIN?SPECIFIC ANGIOGENESIS INHIBITOR 1.- Appendix: Mammalian
PRODUCT DETAILS
Publisher: Springer (Springer-Verlag New York Inc.)
Publication date: January, 2011
Pages: 222
Weight: 623g
Availability: Available
Subcategories: General Issues, Physiology
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