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Main description:
Coxiella burnetii is the etiological agent of Q fever, a zoonotic disease found worldwide. The bacterium is a fascinating example of intracellular parasitism that has uniquely evolved to thrive in the most inhospitable of cellular compartments-the phagolysosome. Understanding how C. burnetii resists the degradative functions of this vacuole, and the host cell functions coopted for successful parasitism, are central to understanding Q fever pathogenesis. Recent achievements in glycomics and proteomics are guiding development of enhanced detection schemes for the bacterium in addition to shedding light on the host immune response to the pathogen. Several chapters survey immune functions that control or potentially exacerbate Coxiella infection and delve into correlates of protective immunity elicited by vaccination. Comparative genomics is also the foundation of chapters discussing diagnostic antigen discovery and molecular typing of the bacterium, with significance for development of new clinical, epidemiologic, and forensic tools.
Contents:
1. History and prospects of Coxiella burnetii research; Karim E. Hechemy
2. Phylogenetic diversity, virulence and comparative genomics; Erin J. van Schaik and James E. Samuel
3. Defense mechanisms against oxidative stress in Coxiella burnetii: Adaptation to a unique intracellular niche; Katja Mertens and James E. Samuel
4. Lipopolysaccharide of Coxiella burnetii; Craig T. Narasaki and Rudolf Toman
5. Components of protective immunity; Guoquan Zhang, Yan Zhang and James Samuel
6. Proteome of Coxiella burnetii; Robert Ihnatko, Edward Shaw and Rudolf Toman
7. Coxiella subversion of intracellular host signaling; S. Kauser Hussain and Daniel E. Voth
8. The Coxiella burnetii parasitophorous vacuole; Eric Ghigo, Maria I. Colombo and Robert A. Heinzen
9. Coxiella burnetii secretion systems; Justin A. McDonough, Hayley J. Newton and Craig R. Roy
10. Role of lipids in Coxiella burnetii infection; Stacey D. Gilk
11. Axenic growth of Coxiella burnetii; Anders Omsland
12. Developmental biology of Coxiella burnetii; Michael F. Minnick and Rahul Raghavan
13. Genetic manipulation of Coxiella burnetii; Paul A. Beare
14. Role of innate and adaptive immunity in the control of Q fever; Christian Capo and Jean-Louis Mege
15. Immune response and Coxiella burnetii invasion; Amira Ben Amara, Yassina Bechah and Jean-Louis Mege
16. Antigenic analysis for vaccines and diagnostics; Laura R. Hendrix and Chen Chen
17. Epidemic Q Fever in humans in the Netherlands; Wim van der Hoek, Gabriella Morroy, Nicole H.M. Renders, Peter C. Wever, Mirjam H.A. Hermans, Alexander C.A.P. Leenders, and Peter M. Schneeberger
18. Coxiella-like endosymbionts; Jianmin Zhong
19. Molecular typing of Coxiella burnetii (Q fever); Robert Massung, Sally Cutler and Dimitrios Frangoulidis
PRODUCT DETAILS
Publisher: Springer
Publication date: June, 2012
Pages: 420
Weight: 793g
Availability: Available
Subcategories: General Issues, Infectious Diseases
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