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Main description:
Sixteen years have passed since human aquaporin-1 (AQP1) was discovered as the first water channel, facilitating trans-membrane water fluxes. Subsequent years of research showed that the water channel AQP1 was only the tip of an iceberg; the iceberg itself being the ubiquitous super family of membrane intrinsic proteins (MIPs) that facilitate trans-membrane transport of water and an increasing number of small, water-soluble and uncharged compounds. Here we introduce you to the superfamily of MIPs and provide a summary about our gradually refined understanding of the phylogenetic relationship of its members. This volume is dedicated to the metalloids, a recently discovered group of substrates for a number of specific MIPs in a diverse spectrum of organisms. Particular focus is given to the essential boron, the beneficial silicon and the highly toxic arsenic. The respective MIP isoforms that facilitate the transport of these metalloids include members from several clades of the phylogenetic tree, suggesting that metalloid transport is an ancient function within this family of channel proteins. Among all the various substrates that have been shown to be transported by MIPs, metalloids take an outstanding position. While water transport seems to be a common function of many MIPs, single isoforms in plants have been identified as being crucially important for the uptake of boric acid as well as silicic acid. Here, the function seems not to be redundant, as mutations in those genes render plants deficient in boron and silicon, respectively.
Contents:
1. Aquaporins: A Family of Highly Regulate d Multifunctional Channels
Charles Hachez and Francois Chaumont
Abstract
Introduction-The Discovery of Aquaporins
Topology of Aquaporins
Selectivity of Aquaporins
Measurement of Aquaporin Activity and Water Movement
Aquaporin Inhibition
Phenotype Analysis Reveals Involvement of Aquaporins in Key Physiological Processes
Aquaporin Regulation: Gating and Localization
Conclusion
2. Phylogeny of Major Intrinsic Proteins
Jonas A.H. Danielson and Urban Johanson
Abstract
Introduction
A Historical Account of the MIP Phylogeny
Plant MIPs
Phylogenetic Analysis of NIPs
Solute Transport
NIP?Like Bacterial MIPs and Ancestral State of ar/R Filter
Conclusion
3. Metalloids, Soil Chemistry and the Environment
Enzo Lombi and Peter E. Holm
Abstract
Introduction
Historical Perspective
Environmental Relevance
Factors Controlling Bioavailability
Assessing Soil Bioavailability of Metalloids
Conclusion
4. Arsenic Transport in Prokaryotes and Eukaryotic Microbes
Barry P. Rosen and Markus J. Tamas
Abstract
Introduction
Metalloid Transport in Prokaryotes
Metalloid Transport in Eukaryotic Microbes
Conclusion
5. Metalloid Transport by Aquaglyceroporins: Consequences in the Treatment of Human Diseases
Rita Mukhopadhyay and Eric Beitz
Abstract
Introduction
Metalloids and Cancer
Uptake of Metalloids via Human Aquaglyceroporins
Metalloids in Protozoan Parasitic Infections
Parasite Aquaglyceroporins Facilitate Metalloid Transport
Therapeutic Modulation of AQP Permeability
Conclusion
6. Roles of Vertebrate Aquaglyceroporins in Arsenic Transport and Detoxification
Zijuan Liu
Abstract
Introduction
Expression of Vertebrate Aquaglyceroporins
Arsenic Is Both an Environmental Toxin and Human Carcinogen
Uptake of Organic and Inorganic Arsenic via Aquaglyceroporins
Molecular Mechanisms for Arsenic Translocation by Aquaglyceroporins
Arsenic Toxicity in Relation of Aquaglyceroporins Regulation
Perspectives
Conclusion
7. Molecular Mechanisms of Boron Transportin Plants: Involvement of Arabidopsis NIP5;1 and NIP6;1
Kyoko Miwa, Mayuki Tanaka, Takehiro Kamiya and Toru Fujiwara
Abstract
Physiological Function of Boron in Plants
Physiological Analysis of B Transport
Molecular Mechanisms of B Transport
Improvement of Plant Growth Property through BOR and NIP Transporters
Conclusion and Foresights
8. Silicon Transporters in Higher Plants
Jian Feng Ma
Abstract
Introduction
Silicon Transporters
Influx Si Transporters
Efflux Transporter of Silicon
Difference in Si Uptake System between Paddy and Field Crops
Silicon Transporters for Xylem Unloading
Conclusion
9. Major Intrinsic Proteins and Arsenic Transport in Plants: New Players and Their Potential Roles
Gerd P. Bienert and Thomas P. Jahn
Abstract
Introduction
The Challenge of As Speciation in Plants
Transport of As in Plants
What Do the Different "Omics" Tell Us About NIP?Mediated As Transmembrane Transport?
The Physiological Role of NIPs
Plant NIPs Transport Trivalent Antimony
Conclusion
10. Major Intrinsic Proteins in Biomimetic Membranes
Claus Helix Nielsen
Abstract
Introduction
Biomimetic Membranes
MIP Biomimetic Membranes and Osmotic Processes
Conclusion
Index
PRODUCT DETAILS
Publisher: Springer (Springer-Verlag New York Inc.)
Publication date: May, 2010
Pages: 162
Weight: 652g
Availability: Available
Subcategories: General Issues
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