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Main description:
Dr. Elisabeth Bock (Photo Keenpress) This book contains review articles that produce a snapshot of recent developments in the field of the neural cell adhesion molecule NCAM. The chapters are grouped into sections reflecting various aspects of NCAM structure and function. The themes cover the structural basis of cell adhesion mediated by NCAM and NCAM interaction partners, NCAM-mediated signaling determinants of NCAM function under physiological conditions and in disease, and the therapeutic potential of NCAM mimetics. Section 1, "Structure and Ligands of NCAM," introduces the reader to the str- tural basis of NCAM-mediated cell adhesion, discussing the current knowledge of extracellular and intracellular NCAM ligands and the structural basis of NCAM int- actions with the fibroblast growth factor (FGF) receptor. Section 2, "NCAM and Polysialic Acid," focuses on NCAM polysialylation, discussing the structural and functional aspects of the most important posttranslational modifications of NCAM by the addition of a long linear homopolymer of sialic acid to the fifth Ig-like NCAM module.
Section 3, "NCAM-mediated Signal Transduction," is devoted to signal v BookID 187530_ChapID FM1_Proof# 1 - 01/03/2011 BookID 187530_ChapID FM1_Proof# 1 - 01/03/2011 vi Preface transduction mechanisms associated with NCAM-mediated adhesion, with a focus on signaling pathways involved in NCAM-mediated neurite outgrowth, the role of growth-associated proteins, signaling through lipid microdomains, and signaling crosstalk with the epidermal growth factor (EGF) receptor. Section 4, "NCAM Metabolism," focuses on current knowledge about NCAM biosynthesis and the g- eration and role of soluble NCAM.
Contents:
Preface Structural Biology of NCAM
Vladislav Soroka, Christina Kasper and Flemming M. Poulsen
Extracellular Protein Interactions Mediated by NCAM: Heterophilic Interactions between NCAM and Cell Adhesion Molecules, Extracellular Matrix Proteins, and Viruses
Janne Nielsen, Nikolaj Kulahin and Peter S. Walmod
Intracellular Ligands of NCAM
Bettina Buttner and Rudiger Horstkorte
NCAM and the FGF receptor
Vladislav V. Kiselyov
The Role of ATP in the Regulation of NCAM Function
Martin V. Hubschmann and Galina Skladchikova
Polysialylation of NCAM
Herbert Hildebrandt, Martina Muhlenhoff and Rita Gerardy-Schahn
Structural Basis for the Polysialylation of NCAM
Karen J. Colley
The Role of PSA-NCAM in Adult Neurogenesis
Eduardo Gascon, Laszlo Vutskits and Jozsef Zoltan Kiss
Use of PSA-NCAM in Repair of the Central Nervous System
Abderrahman El Maarouf and Urs Rutishauser
Signaling Pathways Involved in NCAM-induced Neurite Outgrowth
Dorte Kornerup Ditlevsen and Kateryna Kolkova
Role of Growth-Associated Protein GAP-43 in NCAM-mediated Neurite Outgrowth
Irina Korshunova, Mark Mosevitsky
NCAM and Lipid Rafts
Gro Klitgaard Povlsen and Dorte Kornerup Ditlevsen
NCAM and Epidermal Growth Factor Receptor: Signaling Crosstalk
Gro Klitgaard Povlsen
Biosynthesis of NCAM
Kateryna Kolkova
Soluble NCAM
Thomas Secher
Role of NCAM in Spine Dynamics and Synaptogenesis
Dominique Muller, Pablo Mendez, Mathias De Roo, Paul Klauser, S. Steen and Lorenzo Poglia
NCAM in Long-termPotentiation and Learning
Barbara P. Hartz and Lars Christian B. Ronn
Role of NCAM in Emotion and Learning
Lisa Conboy, Reto Bisaz, Kamila Markram and Carmen Sandi
NCAM in Neuropsychiatric and Neurodegenerative Disorders
Leann H. Brennaman and Patricia F. Maness
NCAM in Cancer: Expression and Mechanisms
Silvia Zecchini and Ugo Cavallaro
NCAM Mimetic Peptides: An Update
Vladimir Berezin and Elisabeth Bock
Synthetic NCAM-derived Ligands of the FGF receptor
Stine Maria Hansen, Shizhong Li, Elisabeth Bock and Vladimir Berezin
Dendritic Spine and Synapse Morphological Alterations Induced by an NCAM Mimetic
Michael Stewart, Victor Popov, Nilolai Medvedev, Paul Gabbott, Nicola Corbett, Igor Kraev and Heather Davies
Fasciclin II: The NCAM Ortholog in Drosophila melanogaster
Lars V. Kristiansen and Michael Hortsch
The Neural Cell Adhesion Molecule NCAM2/OCAM/RNCAM: A Close Relative of NCAM
Nikolaj Kulahin and Peter S. Walmod
Honoring Dr. Elisabeth Bock
Vladimir Berezin
PRODUCT DETAILS
Publisher: Springer (Springer-Verlag New York Inc.)
Publication date: February, 2012
Pages: 450
Weight: 688g
Availability: Available
Subcategories: Neurology, Neuroscience, Physiology
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