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Main description:
This volume contains the papers which were presented at the Third International Symposium on Oxygen Transport to Tissue together with the discussions at the end of each Session. The meeting was held at Churchill College, Cambridge from July 4th-7th 1977. Our special thanks are due to Mrs. Valerie Jeal and Mr. Charles Drown of the Department of Pathology, Bristol, who were invaluable in ensuring the smooth running of the meeting and the preparation of this book. We are very grateful to Dr. Marian Silver for proof-reading and helping to disentangle the "discussion". We would also express our thanks for the general help received from Janet and Fiona Silver and Steven James and our appreciation of the cheerful assistance of Miss Sadie Williams in putting the finishing touches to the manuscript. August, 1977 I. A. Silver M. Erecinska H. I. Bicher Contents Session 1 - OXYGEN ELECTRODES AND BLOOD MONITORING DEVICES The Bitumen P0 Electrode - A New Method to 2 Manufacture P0 Needle Electrodes 3 2 H. Acker, D. Sylvester, E. Dufau, and H. Durst A Working Equation for Oxygen Sensing Disk Electrodes * * * * * * 9 T. E. Tang, R. E. Barr, V. G. Murphy, and A. W. Hahn Variations on the Response Characteristics of Oxygen Electrodes **** 17 R. E. Barr, T. E. Tang, and A. W. Hahn Directly Heated Transcutaneous Oxygen Sensor 25 H. P. Kimmich, J. G. Spaan, and F.
Contents:
Session 1 - Oxygen Electrodes and Blood Monitoring Devices.- The Bitumen PO2 Electrode - A New Method to Manufacture PO2 Needle Electrodes.- A Working Equation for Oxygen Sensing Disk Electrodes.- Variations on the Response Characteristics of Oxygen Electrodes.- Directly Heated Transcutaneous Oxygen Sensor.- A Self-Calibrating, Continuous in vivo PO2 and PCO2 Monitor.- Thin Ring PO2 Electrode Using Gold Paste and Its Application to the Study of the Effects of Venous Occlusion on Skin PO2.- How to Quantify Skeletal Muscle Capillarity.- Staining of PO2 Measuring Points Demonstrated for the Rat Brain Cortex.- Discussion.- Session 2 - Optical Methods.- First Cryophotometric Measurements of the HbO2 Saturation in the Cat Carotid Body.- Multiple Wavelength Reflectance Oximetry in Peripheral Tissues.- Myoglobin Saturation and Calculated PO2 in Single Cells of Resting Gracilis Muscles.- The Myoglobin Probed Optical Studies of Myocardial Energy Metabolism.- The Intracellular Heterogeneity of Oxygen Concentrations as Measured by Ultraviolet Television Microscopy of PBA Fluorescence Quenching by Oxygen.- Application of the Optode Measurements of Surface PO2 and PCO2 of the Isolated Guinea-Pig Heart.- A New Method for Measuring the Oxygen Content in Microliter Samples of Gases and Liquids: The Oxygen Cuvette.- Factors Influencing the Correction Factor Used to Eliminate the Apparent NADH Fluorescence Changes Caused by Alterations in Cerebrocortical Blood Content.- Organ Absorbance and Fluorescence Spectrophotometry and Its Application to Oxygen-Dependent Parameters.- An Experimental Model of the Krogh Tissue Cylinder: Two-Dimensional Quantitation of the Oxygen Gradient.- Discussion.- Session 3 - Model Systems.- Multi-Capillary Model for Oxygen Transport to Skeletal Tissue.- Dynamic Hypoxic Hypoxemia in Brain Tissue: Experimental and Theoretical Methodologies.- Mathematical Model of Respiratory Gas Exchange at Stationary Conditions.- Calculation of the Facilitation of O2 or CO Transport by Hb or Mb by Means of a New Method for Solving the Carrier-Diffusion Problem.- The Effect of Deoxygenation Rate of the Erythrocyte on Oxygen Transport to the Cardiac Muscle.- Gas Transfer Through the Skin: A Two-Layer Model Relating Transcutaneous Flux to Arterial Tension.- Electrical Potentials During Carbon Dioxide Transport in Hemoglobin Solutions.- Interpretation of Oxygen Disappearance Rates in Brain Cortex Following Total Ischaemia.- Analysis of Oxygen Transport in Bullfrogs.- Distribution of Intracapillary O2-Supply and Tissue PO2 in Canine Left Ventricle During Normoxia - An Analysis of Kryophotometrically Measured HbO2 Saturation with a Diffusion Model.- Metabolism Prediction Based on Measurement of PO2 and Flow at the Same Locus During Seizures and Barbiturate Suppression of EEG.- A Computer Analysis of Graded Ischemia in Brain.- A Comparison of Two Nonclassical Models for Oxygen Consumption in Brain and Liver Tissue.- Models for Pulsed Polarographic Electrodes.- Mathematical Simulation of Oxygen and Carbon Dioxide Transport in Fetal Brain.- Some Effects of High Altitude and Polycythaemia on Oxygen Delivery.- The Theoretical Effect of DPG Upon Oxygen Diffusion in Erythrocytes.- Discussion.- Session 4 - Cellular Respiration and O2 Transport.- On the Mechanism of Regulation of Cellular Respiration. The Dependence of Respiration on the Cytosolic [ATP], [ADP], and [Pi].- Regulation of Mitochondrial Respiration in Intact Tissues: A Mathematical Model.- In vivo Studies of Mitochondrial Respiration.- Induction by Hypoxia of a New Haemoglobin-Like Pigment.- Myoglobin-O2-Saturation Profiles in Muscle Sections of Chicken Gizzard and the Facilitated O2 Transport by Mb.- Simultaneous Measurement of Glucose and O2 Consumption in Cell Suspensions with Minielectrodes.- Density Dependent Energy Changes and Adaptive Growth in Populations of Mouse Fibroblasts in vitro.- Direct Determination of Local Oxygen Consumption of the Brain Cortex in vivo.- Study of Tissue Oxygen Gradients by Single and Multiple Indicators.- Discussion.- Session 5 - Oxygen, Radiation, and Neoplasia.- Increase in Brain Tissue Oxygen Availability Induced by Localized Microwave Hyperthermia.- A Pulse-Radiolysis Study on Active Oxygen.- Oxygen Diffusion Constants D and K of Tumor Tissue (DS-Carcinosarcoma) and Their Temperature Dependence.- Intracapillary HbO2 Saturation in Tumor Tissue of DS-Carcinosarcoma During Normoxia.- Oxygen Levels in Tumors in C3H Mice During Hyperthermia: Initial Data.- Prevention of Ionizing Radiation-Induced Liver Microcirculation Changes by the Use of Flow Improvers.- Discussion.- Session 6 - Oxygen Transport in Disease.- Oxygen Transport Impairment Induced by Three Major Cardiovascular Risk Factors.- Oxygen Pressure Values in the Ischemic Muscle Tissue of Patients with Chronic Occlusive Arterial Disease.- Computer Simulation of the Human Thoracic Aorta to Evaluate the Possible Role of Smoking in Atherogenesis.- Synchronous Tracer Injection for O2 Uptake and CO2 Production Measurement.- Measurements of Local Oxygen Pressure in Skeletal Muscle of Patients Suffering from Disturbances of Arterial Circulation.- Increased Hemoglobin-Oxygen Affinity in Patients with Pancreatitis Associated with Type I and V Hyperlipoproteinemia.- Effects of Coronary Occlusion on Myocardial Oxygen and Pulsatile Intramyocardial Pressure.- Homeostatic Responses to Increased Oxygen Affinity.- Hemoglobin-Oxygen Affinity in Organic Heart Disease.- Discussion.- Session 7 - Fetal and Maternal Oxygenation.- Microelectrode Studies in the Brain of Fetal Rats and New Born Rats.- The Effect of Acidosis on Red Cell 2,3-DPG and Oxygen Affinity of Whole Fetal Blood.- Oxygen Affinity Changes in the Red Cells of Embryonic and Neonatal Mice.- Temporal Correlations Between Plasma Ovarian Steroid Hormone Levels and Intrauterine Oxygen Tension in the Guinea Pig.- Oxygen Consumption and Oxygen Diffusion in Isolated Human Term Placental Lobules Perfused in vitro.- Hemodynamics and Oxygen Diffusion in the Cotyledon of the Human Placenta.- Respiratory Gas Transport in Blood During Pregnancy with Hemoglobin Concentrations Below 12g/100ml.- Discussion.- Session 8 - Hypoxia, Ischemia, Shock.- Relationship Between Erythropoietin Levels and Intrarenal Oxygenation During Anuric Hemorrhagic Shock.- Modifications of Somatosensory Evoked Cortical Potentials During Hypoxia in the Awake Rabbit.- Tissue-PO2 (PGO2) in the Carotid Body of the Cat and the Tidal Volume (V) during Normovolaemic Haemodilution.- Oxygen Extraction in Severely Anemic Dogs After Infusion of NaHCO3 or HCl.- The Effect of Dextrose/Insulin Infusion on the Duration of Respiratory Activity in the Anoxic Rat.- Oxygen Consumption and Oxygen Extraction of the Feline Liver Under Different Types of Induced Hypoxia.- The Effects of Low O2 Supply on the Respiratory Activity, Reduced Pyridine Nucleotide Fluorescence, K+ Efflux and the Surface PO2 and PCO2 of the Isolated, Perfused Rat Liver.- Disturbances of Extracellular pK, pNa, and pH During No-Flow Anoxia.- Cytochrome Oxidase and Urate Oxidase as Intracellular O2 Indicators in Studies of O2 Gradients During Hypoxia in Liver.- Flow Stasis, Blood Gases and Glucose Levels in the Red Pulp of the Spleen.- Intestinal O2 Consumption Under Low Flow Conditions in Anaesthetized Cats.- Tissue Blood Exchange and Tissue Oxygen Tension in Relation to Total Body Oxygen Consumption in Experimental Surgical Shock.- Skeletal Muscle PO2: Indicator of Peripheral Tissue Perfusion in Haemorrhagic Shock.- Monitoring of Tissue PO2 in Patients During Intensive Care.- Enhancement of CO2-Elimination by Intrapulmonary High Frequency Pressure Alternating During "Apnoeic Oxygenation".- Changes in Cerebrocortical PO2 -Distribution, rCBF and EEG During Hypovolemic Shock.- Extracellular K+ and H+ Activities in the Brain Cortex During and After a Short Period of Ischaemia and Arterial Hypoxia.- Regional Hemodynamic and Metabolic Alterations in Focal Cerebral Ischemia: Studies of Diaschisis.- Oxygen and Carbon Dioxide Tensions in the Gastrocnemius Muscles of Patients with Lower Limb Arterial Ischaemia.- Effects of Ischemia on the Oxygen Diffusion Coefficients in the Brain Cortex.- Oxygen Supply to the Cirrhotic Liver Following Various Portacaval Shunt Procedures.- PO2 Histograms and Extracellular Activity of K+ of Skeletal Muscle in Tourniquet Shock.- Effect of Ouabain on Cortical Potassium Activity During Anoxic Depolarization.- The Size of the Hypoxic Zone at the Border of an Anoxic Region Within the Tissue.- Discussion.- Session 9 - Tissue PO2 and Cell Function.- The Effect of Chronic Hypoxia on Wound Healing.- Oxygen and Epidermal Wound Healing.- Oxygen Pressure and Ictal Activity in the Cerebral Cortex of Artifically Ventilated Rats During Exposure to Oxygen High Pressure.- Simultaneous Measurement of PO2 and Flow at the Same Locus During Seizures and Barbiturate Suppression of EEG.- The Sensitivity of Aplysia Giant Neurons to Changes in Extracellular and Intracellular PO2.- Oxygen Diffusion, Conductivity and Solubility Coefficients in the Microarea of the Brain.- Transient Metabolic and Vascular Volume Changes Following Rapid Blood Pressure Alterations Which Precede the Autoregulatory Vasodilation of Cerebrocortical Vessels.- The Influence of Electrical Stimulation on Cortex PO2 Level in the Rat Brain.- Local Tissue PO2 in Kidney Surgery and Transplantation.- Measurements of Oxygen Partial Pressure and Single-Unit Action Potentials in the Parieto-Visceral Ganglion of Aplysia californica.- The Responses of an Awake Brain to HPO Under Increased CO2 Concentrations.- Oxygen Transport to the Inner Ear.- Kinetics of Changes in PO2 and Extracellular Potassium Activity in Stimulated Rat Sympathetic Ganglia.- Evidence for Existence of Intramyocardial Steal.- The Interrelation Between CBF, Energy Metabolism and ECoG in a New Awake Brain Model.- Tissue PO2 Changes in Acute Inflammation.- Thresholds of Ischaemia in Brain Cortex.- Discussion.
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Publisher: Springer (Springer-Verlag New York Inc.)
Publication date: November, 2012
Pages: 796
Weight: 1525g
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Subcategories: Haematology
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Shahidul Islam
Joe G. Hollyfield
Jeremy P. T. Ward
Ikuo Homma
Ramkrishna Sen
Rahul Jandial
Jose Luis Pedraz
Vladimir Berezin
Vassilis Cutsuridis
Srinivasa T. Reddy
Duane F. Bruley
Katalin Balogh
Jean-Francois Jeannin
Yongwon Choi
Kenneth Maiese
Padraic G. Fallon
Carmen Espinos
Inke S. Nathke
Carlos A. Guzman
Uday Kishore
Carlos Lopez-Larrea
Pierre Ferrier
R. Jeroen Pasterkamp
Constancio Gonzalez
Susan Valle
Iqbal S. Grewal
Per Liss
Dagmar Sternad
Stephen W. Schaffer
Gail Ruth Goldberg
Nigel G. Laing
Stephen P. Schoenberger
Peter Gunning
Alexander Sigalov
John D. Lambris
C.Y. Cheng
Gary B. Huffnagle
Miguel Maroto
Miguel Maroto
Shamim I. Ahmad
Ryutaro Utsumi
Lev M. Berstein
Andrew Berchuck
Gerhard Martin Technau
H. Kenneth Hudnell
Jonathan J. Li
Jorg Reichrath
Jon F. Wilkins
Hemanta K. Majumder
Benjamin J. Blencowe
Duane F. Bruley
Dominique Bagnard
Roya Khosravi-Far
Peter D Wagner
Joe G. Hollyfield
Alberto Mantovani
Warren C.W. Chan
Alexander I. Agoulnik
Richard Wilson
Yongwon Choi
Robert D. Perry
Dihua Yu
Gáspár Jékely
John D. Lambris
Duane F. Bruley
Michael R. Shurin
Fabrizio d'Adda di Fagagna
Gerard Pasterkamp
Bharat B. Aggarwal
Vicente Felipo
Setsuro Ebashi
Stephen P. Schoenberger
Simone Mocellin
Peter D Wagner
John P. Fisher
Stanley Perlman
Jean-Pierre Saint-Jeannet
Simo S. Oja
Duane F. Bruley
John D. Lambris
Constantine Tsoukas
Nagy A. Habib
Uwe Lendeckel
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Joseph T. Coyle
Richard Blumberg
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Marelyn Wintour-Coghlan
Joe G. Hollyfield