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Main description:
A panel of leading investigators summarizes and synthesizes the new discoveries in the rapidly evolving field of histone acetylation as a key regulatory mechanism for gene expression. The authors describe what has been learned about these proteins, including the identification of the enzymes, the elucidation of the enzymatic mechanisms of action, and the identification of their substrates and their partners. They also review the structures that have been solved for a number of enzymes-both alone and in complex with small molecule inhibitors-and the biological roles of the several histone deacetylases (HDAC) genes that have been knocked out in mice.
Contents:
I. Class I Histone Deacetylases
Histone Deacetylase 1
Dominique Meunier and Christian Seiser
Biochemistry of Multiprotein HDAC Complexes
Alejandro Vaquero, Michael Scher, and Danny Reinberg
The Biology of HDAC3
Edward Seto
The Biology of HDAC8, a Unique Class I Histone Deacetylase
David Waltregny and Vincent Castronovo
II. Class II Histone Deacetylases
Regulation of Muscle Gene Expression by Histone Deacetylases
Timothy A. McKinsey and Eric N. Olson
The Class IIa Histone Deacetylases: Functions and Regulation
Herbert G. Kasler and Eric Verdin
Histone Deacetylases in the Response to Misfolded Proteins
J. Andrew McKee and Tso-Pang Yao
III. Class III Histone Deacetylases
Comparison of Sirtuin Sequences Between Archaea and Vertebrates
Roy A. Frye
Structure of the Sir2 Family of NAD+-Dependent Histone/Protein Deacetylases
Kehao Zhao and Ronen Marmorstein
The Enzymology of SIR2 Proteins
Margie T. Borra and John M. Denu
The Class III Protein Deacetylases: Homologs of Yeast Sir2p
Bjoern Schwer, Brian J. North, Nidhi Ahuja, Brett Marshall, and Eric Verdin
IV. Histone Deacetylase Inhibitors
HDAC Inhibitors: Discovery, Development, and Clinical Impacts
Akihiro Ito, Norikazu Nishino, and Minoru Yoshida
Cell Cycle Targets of Histone Deacetylase Inhibitors
Brian Gabrielli
HDAC Inhibitors: An Emerging Anticancer Therapeutic Strategy
Paul Kwon, Meier Hsu, Dalia Cohen, and Peter Atadja
Index
PRODUCT DETAILS
Publisher: Springer (Humana Press Inc.)
Publication date: November, 2010
Pages: 352
Weight: 598g
Availability: Available
Subcategories: Oncology
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