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Deoxynucleoside Analogs in Cancer Therapy
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Main description:

Successful cancer chemotherapy relies heavily on the application of various deoxynucleoside analogs. Since the very beginning of modern cancer chemotherapy, a number of antimetabolites have been introduced into the clinic and subsequently applied widely for the treatment of many malignancies, both solid tumors and hematological disorders. In the latter diseases, cytarabine has been the mainstay of treatment of acute myeloid leukemia. Although many novel compounds were synthesized in the 1980s and 1990s, no real improvement was made. However, novel technology is now capable of elucidating the molecular basis of several inborn errors as well as some specific malignancies. This has enabled the synthesis of several deoxynucleoside analogs that could be applied for specific malignancies, such as pentostatin and subsequently chlorodeoxyadenosine (cladribine) for the treatment of hairy cell leukemia. Already in the early stage of deoxynucleoside analog development, it was recognized that several of these compounds were very effective in the treatment of various viral infections, such as for the treatment of herpes infections. This formed the basis initially for the design of azidothymidine and subsequently many other analogs, which are currently successfully used for the treatment of HIV infections. As a spin-off of these research lines, some compounds not eligible for development as antiviral agents appeared to be very potent anticancer agents. The classical example is gemcitabine, now one of the most widely applied deoxynucleoside analogs, used for the (combination) treatment of non-small cell lung cancer, pancreatic cancer, bladder cancer, and ovarian cancer.


Contents:

Nucleoside Transport into Cells: The Role of Nucleoside Transporters SLC28 and SLC29 in Cancer Chemotherapy
Marcal Pastor-Anglada and F. Javier Casado

The Role of Deoxycytidine Kinase in DNA Synthesis and Nucleoside Analog Activation
Maria Staub and Staffan Eriksson

Deoxynucleoside Kinases and Their Potential Role in Deoxynucleoside Cytotoxicity
Birgitte Munch-Petersen and Jure Piskur

Nucleotidases and Nucleoside Analog Cytotoxicity
Sally Anne Hunsucker, Beverly S. Mitchell, and Jozef Spychala

Pumping Out Drugs: The Potential Impact of ABC Transporters on Resistance to Base, Nucleoside, and Nucleotide Analogs
Piet Borst and Peter Wielinga

Cytosine Arabinoside: Metabolism, Mechanisms, of Resistance, and Clinical Pharmacology
Isabelle Hubeek, G. J. L. Kaspers, G Ossenkoppele, and G. J. Peters

Clofarabine: Mechanisms of Action, Pharmacology, and Clinical Investigation
Varsha Gandhi and William Plunkett

L-Nucleosides as Chemotherapeutic Agents
Giuseppe Gumina, Youhoon Chong, and Chung K. Chu

Troxacitabine: A Deoxycytidine Nucleoside Analogue With Potent Antitumor Activity
Henriette Gourdeau and Jacques Jolivet

9-b-D-arabinofuranosylguanine
Sophie Curbo

Gemcitabine: Mechanism of Action and Resistance
A. M. Bergman and G.J. Peters

Clinical Activity of Gemcitabine as a Single Agent and in Combination
J. R. Kroep, GJ Peters, and RA Nagourney

Nucleoside Radiosensitizers
Donna S. Shewach and Theodore S. Lawrence

NONMEM Population Models of Cytosine Arabinoside and Flubaradine Phosphate in Pediatric Patients with Leukemia
Vassilios I. Avramis

The cycloSal-Nucleotide Delivery System: Development of Chemical Trojan Horses as Antiviral Agents
Chris Meier, Jan Balzarini, and Astrid Meerbach

Purine and Pyrimidine Based Analogs and Suicide GeneTherapy
Zoran Gojkovic

3'-deoxy-3'- Fluorothymidine as a Tracer if Proliferation in Positron Emission Tomography


PRODUCT DETAILS

ISBN-13: 9781617374975
Publisher: Springer (Humana Press Inc.)
Publication date: November, 2010
Pages: 492
Weight: 717g
Availability: Available
Subcategories: Oncology
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