(To see other currencies, click on price)
MORE ABOUT THIS BOOK
Main description:
The revelation that aspirin and aspirin-like compounds have notableantineo plastic properties has revolutionized cancer research. COX-2 Blockade in Cancer Prevention and Therapy chronicles the evidence and presents exciting new op portunities for the use of cyclooxygenase-2 (COX-2) blockade in the prevention and treatment of cancer. The text is divided broadly into five areas. First, an historical overview documents the scientific discovery ofCOX-2 and the pharma ceutical development of nonsteroidal anti-inflammatory drugs (NSAIDs) designed for selective COX-2 inhibition. The process by which essential poly unsaturated fatty acids (PUF As) stimulate prostaglandin biosynthesis and cancer development, and its interruption by COX-2 inhibition, is elucidated. This is followed by a section on the epidemiology of NSAIDs and cancers of the colon and breast, and other anatomic sites. These chapters reflect significant cancer protection owing to the regular use of common NSAIDs such as aspirin and ibuprofen. A section on animal models of carcinogenesis presents comprehensive evidence that general NSAIDs inhibit a variety of malignant neoplasms in vivo, and highlights recent findings which show that COX-2 blocking agents produce striking chemopreventive effects against colon cancer and breast cancer as well as other malignancies. Genetic models are presented confirming the critical role of COX-2 in carcinogenesis. Section IV then discusses the molecular biology of COX -2 vis-a-vis the role of COX -2 and, to a lesser extent, COX -1, in modulating a number of important processes in molecular carcinogenesis such as mutagen esis, cell division, angiogenesis, cell differentiation, and apoptosis.
Contents:
Part I. Historical Perspectives
Dietary Fatty Acids, COX-2 Blockade, and Carcinogenesis
Rashida A. Karmali
Historical Aspects of COX-2: Cloning and Characterization of the cDNA, Protein and Gene
Harvey R. Herschman
Part II. Epidemiology of NSAIDs and Cancer
Epidemiology of Nonsteroidal Anti-Inflammatory Drugs and Colorectal Cancer
Michael J. Thun and S. Jane Henley
Epidemiology of Breast Cancer and Nonsteroidal Anti-Inflammatory Drugs: Extension of the Dietary Fat Hypothesis of Breast Cancer
Randall E. Harris
Part III. Animal Models of Carcinogenesis
Role of Synthetic and Naturally Occurring Cyclooxygenase Inhibitors in Colon Cancer Prevention
Bandaru S. Reddy and Chinthalapally V. Rao
Chemoprevention of Breast Cancer by Nonsteroidal Anti-Inflammatory Drugs and Selective COX-2 Blockade in Animals
Hussein M. Abou-Issa, Galal A. Alshafie, and Randall E. Harris
The Role of Cyclooxygenase-2 in the Prevention and Therapy of Lung Cancer
Hildegard M. Schuller
Nonsteroidal Anti-Inflammatory Drugs, Prostaglandins, and Apc-Driven Intestinal Tumorigenesis
Jay Whelan and Michael F. McEntee
Cyclooxygenase-1 and Cyclooxygenase-2 Knockout Mice Provide Insights into Beneficial and Adverse Effects of Nonsteroidal Anti-Inflammatory Drugs
Robert Langenbach
Part IV. Molecular Biology of COX-2
Cyclooxygenase-2, Prostaglandins, and Colorectal Carcinogenesis
Rajnish A. Gupta and Raymond N. DuBois
Regulation of Expression and Potential Carcinogenic Role of Cyclooxygenase-2
Byeong-Churl Jang and Timothy Hla
Cyclooxygenase-2 and Cancer
Alane T. Koki, Kathleen M. Leahy, Janet M. Harmon, and Jaime L. Masferrer
Interactions of Cyclooxygenase and Aromatase Pathways in Normal and Malignant Breast Cells
Jeanette A. Richards and Robert W. Brueggemeier
Association of COX-2 and PPARs in Carcinogenesis and Chemoprevention
Tong-Chuan He
Carcinogenesis Involving Cyclooxygenase and Lipoxygenase
Linda C. Hsi and Thomas E. Eling
Part V. Clinical Applications
The Development of Drugs that Target Cyclooxygenase-2
Timothy Maziasz, K. Nasir Khan, John Talley, James Gierse, and Karen Seibert
Chemoprevention of Cancer by NSAIDs and Selective COX-2 Blockade
Gary J. Kelloff, Vernon E. Steele, and Caroline C. Sigman
Potential for Inhibitors of Cyclooxygenase-2 to Enhance Tumor Radioresponse
Randy Burd, Hak Choy, and Adam Dicker
Potential Role of NSAIDs and COX-2 Blockade in Cancer Therapy
William F. Anderson, Asad Umar, Jaye L. Viner, and Ernest T. Hawk
Cyclooxygenase-2 Blockade in Cancer Prevention and Therapy: Widening the Scope of Impact
Randall E. Harris
Index
PRODUCT DETAILS
Publisher: Springer (Humana Press Inc.)
Publication date: November, 2010
Pages: 384
Weight: 805g
Availability: Available
Subcategories: Oncology
From the same series
