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Cancer Drug Resistance
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Main description:

Leading experts summarize and synthesize the latest discoveries concerning the changes that occur in tumor cells as they develop resistance to anticancer drugs, and suggest new approaches to preventing and overcoming it. The authors review physiological resistance based upon tumor architecture, cellular resistance based on drug transport, epigenetic changes that neutralize or bypass drug cytotoxicity, and genetic changes that alter drug target molecules by decreasing or eliminating drug binding and efficacy. Highlights include new insights into resistance to antiangiogenic therapies, oncogenes and tumor suppressor genes in therapeutic resistance, cancer stem cells, and the development of more effective therapies. There are also new findings on tumor immune escape mechanisms, gene amplification in drug resistance, the molecular determinants of multidrug resistance, and resistance to taxanes and Herceptin.


Back cover:

As genomic techniques gradually reveal the ability of malignant cells to respond to chemical and biological insults with remarkable flexibility of phenotype, it becomes clear that much remains to be done to control and eliminate such cells. In Cancer Drug Resistance, leading scientists from the best academic institutions and industrial laboratories summarize and synthesize the latest discoveries concerning the changes that occur in tumor cells as they develop resistance to a wide variety of anticancer therapeutics, as well as suggest new approaches to the biology of drug resistance that may afford new therapeutic opportunities. The authors review physiological resistance based tumor architecture, cellular resistance based on drug transport, epigenetic changes that neutralize or bypass drug cytotoxicity, and genetic changes that alter drug target molecules by decreasing or eliminating drug binding and efficacy. Highlights include new insights into resistance to antiangiogenic therapies, oncogenes and tumor suppressor genes in therapeutic resistance, cancer stem cells, and the development of more effective therapies. There are also new findings on tumor immune escape mechanisms, gene amplification in drug resistance, the molecular determinants of multidrug resistance, and resistance to taxanes and Herceptin®.

Authoritative and insightful, Cancer Drug Resistance offers basic and clinical investigators a state-of-the-art synthesis of the many faceted research now available on the biology and genetics of tumor resistance, as well as exciting new approaches to its prevention and eradication.


Contents:

Part I. Physiological Resistance

The Cycle Between Angiogenesis, Perfusion, and Hypoxia in Tumors
Mark W. Dewhirst, Yiting Cao, Benjamin Moeller, and Chuan-Yuan Li

Influence of Tumor pH on Therapeutic Response
Chang W. Song, Robert Griffin, and Heon Joo Park

Tumor Oxygenation and Treatment Response
Sarah Jane Lunt and Richard P. Hill

Oncogenes and Tumor Suppressor Genes in Therapeutic Resistance: The Role of Evolving Interrelationships Between Cancer Cells and Host Tissues
Janusz W. Rak, Brenda Coomber, and Joanne L. Yu

PET Imaging of Response and Resistance to Cancer Therapy
David A. Mankoff and Kenneth A. Krohn

Part II: Biological Resistance

Cancer Stem Cells: Implications for Development of More Effective Therapies
Ilia Mantle, Gabriela Dontu, Suling Liu, and Max S. Wicha

Therapeutic Resistance in Leukemia
William R. Waud

Tumor Site Implantation and Animal Model Selection in Oncology
Anibal A. Arjona and Enrique Alvarez

In Vivo Resistance
Beverly A. Teicher

Characteristics of the Metastatic Phenotype: The Melanoma Experience
Vladislava O. Melnikova and Menashe Bar-Eli

The Microenvironment and Drug Resistance
Patrice J. Morin

Part III. Biochemical Resistance

Glutathione and Glutathione S-Transferases in Drug Resistance
Victoria J. Findlay, Danyelle M. Townsend, and Kenneth D. Tew

Metallothioneins in Drug Resistance
Faiyaz Notta and D. James Koropatnick

Molecular Determinants of Intrinsic Multidrug Resistance in Cancer Cells and Tumors
Elena Monti

New and Revised Concepts in Multidrug Resistance: Sestamibi, SNPs, Substrates, and Stem Cells
Susan E. Bates, John Deeken, Chaohong Fan, and Robert W. Robey

Cisplatin Resistance: Molecular Basis of a Multifaceted Impediment
Zahid H. Siddik

Regulation of the Cellular Pharmacology and Cytotoxicity of Cisplatin by Copper Transporters
Roohangiz Safaei and Stephen B. Howell

Resistance to Taxanes
Lee M. Greenberger and Deepak Sampath

CpG Island Methylation and Drug Resistance
Jens M. Teodoridis and Robert Brown

De Novo and Acquired Resistance to Antitumor Alkylating Agents
Lori A. Hazlehurst and William S. Dalton

Resistance to Antiangiogenic Agents
George W. Sledge, Jr., Kathy D. Miller, Bryan Schneider, and Christopher J. Sweeney

Part IV. The Role of Hormones, Growth Factors, and Oncogenes

Resistance to Antiestrogens
Clodia Osipo and Ruth M. O'Regan

Mechanisms of Glucocorticoid Actions and Resistance in Multiple Myeloma
Varsha Gandhi and Beatriz Sanchez-Vega

Herceptin Resistance
Ingrid A. Mayer and Carlos L. Arteaga

Role of TGF-b in Tumor Progression and Metastasis
Jan Pinkas and Beverly A. Teicher

p53-Based Immunotherapy of Cancer
Albert B. DeLeo

Response and Resistance to Ionizing Radiation
Paul Dent, Adly Yacoub, Michael P. Hagan, and Steven Grant

Amplification in DNA Copy Numbers as a Mechanism of Acquired Drug Resistance
M. Jim Yen, Ie-Ming Shih, Victor E. Velculescu, and Tian-Li Wang

Part V. Clinical Aspects of Resistance

Cancer Chemotherapy: Clinical Evidence for Drug Resistance
Mika A. Sovak and David R. Spriggs

Molecular Profiling in Breast Cancer: Genomic Approaches Toward Tailored Cancer Therapies
Kristin Kee and Jeffrey E. Green

Tumor Immune Escape Mechanisms
Yi Ting Koh, M. Luz García-Hernández, and W. Martin Kast

Index


PRODUCT DETAILS

ISBN-13: 9781617376221
Publisher: Springer (Humana Press)
Publication date: December, 2010
Pages: 634
Weight: 1193g
Availability: POD
Subcategories: Oncology
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CUSTOMER REVIEWS

Average Rating 

"...a resource to scientists of diverse specialties with interests relating to the repsonse of malignant disease to current and experimental therapies." - Neoplasma

"...an excellent book that is appropriate for scientists and clinicians with an interest in the basis of anticancer drug resistance." -Doody's Book Review, Weighted Numberical Score: 90 - 4 Stars!