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Oncogene-Directed Therapies
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Main description:

Prominent investigators and clinicians summarize in a balanced blend of fundamental science, basic research, experimental therapeutics, and early clinical experiences, what is known about oncogenes and oncogenesis, and describe how that knowledge can be used to treat the cancer. The contributors explain how, why, and under what conditions certain proteins acquire the ability to transform eukaryotic cells, and detail the crucial biological consequences of this oncogenic transformation, particularly for cellular mitogenesis, survival, differentiation, migration, proteolysis, or angiogenic competence. Their articles thoroughly explicate the premises, principles, techniques, and approaches to oncogene targeting in various types of human cancer by using signal transduction inhibitors, immunological targeting methods, and antisense gene therapy.


Back cover:

In recent years an entirely new category of anticancer agents has entered the clinic. This class of drugs, the frontrunners of which are Herceptin and Gleevec, are no longer a product of the intuitive and largely empirical explorations that brought about traditional anticancer treatments like chemotherapy. Rather, these new agents have emerged directly from molecular analysis of various cancer-causing genes (oncogenes). In Oncogene-Directed Therapies, prominent investigators and clinicians, several of them pioneers in the field, summarize what is known about oncogenes and oncogenesis-in a balanced blend of fundamental science, basic research, experimental therapeutics, and early clinical experience-and describe how that knowledge can be used to treat the disease. The contributors explain how, why, and under what conditions certain proteins acquire the ability to transform eukaryotic cells, and detail the crucial biological consequences of this oncogenic transformation, particularly for cellular mitogenesis, survival, differentiation, migration, proteolysis, or angiogenic competence. Their articles thoroughly explicate the premises, principles, techniques, and approaches to oncogene targeting in various types of human cancer by using signal transduction inhibitors, immunological targeting methods, and antisense gene therapy. Also included is a review of the results of preclinical and clinical testing of some of today's most advanced therapeutic agents.

Unique in perspective and comprehensive in its coverage, Oncogene-Directed Therapies not only integrates for all those engaged in-or simply interested in the cutting-edge of-"the war on cancer" the many remarkable recent achievements in our molecular understanding and treatment of these diseases, but also clarifies what directions future research might optimally take, as well as what significant accomplishments might lie ahead.


Contents:

Part I. Basic Concepts in Oncogene Research

Genetic Basis of Cancer Progression
Susan J. Done and Jeremy A. Squire

The Molecular Basis of Chromosomal Instability in Human Cancer Cells
Daniel P. Cahill

Signal Transduction Networks: Ras as a Paradigm
Frank McCormick

Oncogenic Receptor Tyrosine Kinases
Mark H. Kirschbaum, Mina D. Marmor, and Yosef Yarden

Ras-Mediated Deregulation of Gene Expression and Contribution to Oncogenesis
Gretchen A. Murphy and Channing J. Der

The Interplay Between Tumor Suppressor Genes and Oncogenes in Tumorigenesis
Eric C. Holland

Genetic Basis of Altered Responsiveness of Cancer Cells to Their Microenvironment
Amato J. Giaccia

Part II. The Functional Impact of Oncogene Expression on Cancer Cells-Therapeutic Implications

Deregulation of Cell Cycle Progression by Oncogenic Transformation
Marcelo L. Rodriguez-Puebla, Adrian M. Senderowicz, and Claudio J. Conti

Oncogenes as Regulators of Cell Survival: The Role of Oncogenes and Tumor Suppressor Genes in the Induction of Resistance to Anoikis and Hypoxia
Kirill Rosen and Jorge Filmus

Oncogenes and Tumor Angiogenesis
Janusz Rak and Robert S. Kerbel

Oncogenes as Therapeutic Targets to Prevent Metastasis
Ann F. Chambers and Hemanth J. Varghese

The Impact of Oncogenes on Tumor Maintenance
Senji Shirasawa and Takehiko Sasazuki

Primary and Secondary Events in Oncogene-Driven Tumor Development: Lessons from Transgenic Model Systems
Michaela Herzig and Gerhard Christofori

Part III. Oncogenes as Targets for Anticancer Therapy In Vivo

Targeting Oncogenes in Hematopoietic Malignancies
Michael E. O'Dwyer and Brian J. Druker

Clinical Evaluation of Agents Targeting Epidermal Growth Factor Receptor (EGFR) in Cancer
Edward H. Lin and James L. Abbruzzese

Inhibition of the HER-2/neu Oncogene: A Translational Research Model for the Development of Future Targeted Therapies
Gottfried E. Konecny, Jane Arboleda, Dennis J. Slamon, and Mark Pegram

Farnesyltransferase Inhibitors as Anticancer Agents
Adrienne D. Cox

Targeting Oncogenic Signaling Pathways in Human Astrocytomas
Gelareh Zadeh and Abhijit Guha

Targeting Oncogenes in Pediatric Malignancies
Giannoula Klement and Robert S. Kerbel

Inhibiting Signal Transduction as an Approach to Radiosensitizing Tumor Cells
Eric J. Bernhard, Anjali K. Gupta, Elizabeth Cohen-Jonathan, Ruth J. Muschel, Stephen M. Hahn, and W. Gillies McKenna

Oncogenes as Targets for Cancer Vaccines
Samir N. Khleif and Joseph A. Lucci, III

Bcl-2 Antisense Oligonucleotides Therapy for Cancer: Targeting the Mitochondria
Finbarr E. Cotter and Dean A. Fennell

Index


PRODUCT DETAILS

ISBN-13: 9781468497380
Publisher: Springer (Humana Press)
Publication date: July, 2012
Pages: 487
Weight: 950g
Availability: POD
Subcategories: Oncology
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CUSTOMER REVIEWS

Average Rating 

"The book is well referenced, and readers will easily be able to locate primary literature for in-depth reading on specific topics. The figures and illustrations are extremely useful in summarizing complex topics that are discussed. In summary, this is an unique, well-organized, and timely presentation on a topic of high importance. People who will find this volume especially useful include students of tumor biology, basic scientists with an interest in novel therapeutic or translational research, and all clinicians who are involved in the diagnosis and treatment of patients with cancer." - Neuro-oncology

"This book attempts to cover a vast and rapidly evolving field of research, both basic and clinical, and does so successfully by giving the reader a balanced mix of basic science, experimental therapeutics and clinical observations. Most chapters are richly illustrated and all have extensive lists of relevant references." - Medical Oncology

"...this book will be useful not only to those just starting their research careers, including graduate and medical students, but also to those who have been involved in the field of cancer biology and treatment for a number of years, including seasoned scientists and clinicians." -Doody's Health Sciences Book Review Journal