BOOKS BY CATEGORY
Your Account
Death Receptors in Cancer Therapy
Price
Quantity
£193.00
(To see other currencies, click on price)
Paperback / softback
Add to basket  

MORE ABOUT THIS BOOK

Main description:

An in depth review of our latest understanding of the molecular events that regulate cell death and those molecules that provide targets for developing agonists or antagonists to modulate death signaling for therapeutic purposes. The authors focus on the extrinsic system of death receptors, their regulation and function, and their abnormalities in cancer. Topics of particular interest include resistance to apoptosis, TRAIL signaling, death receptors in embryonic development, mechanisms of caspase activation, and death receptor mutations in cancer. Additional chapters address death signaling in melanoma, synthetic retinoids and death receptors, the role of p53 in death receptor regulation, immune suppression of cancer, and combination therapy with death ligands.


Back cover:

Cell death, or apoptosis, plays an important role in biological processes and disease and offers special opportunities to develop new therapies for cancer, autoimmune disease, stroke, heart attack, and Alzheimer's disease. In Death Receptors in Cancer Therapy, leading physician-scientists and basic researchers review in depth our latest understanding of the molecular events that regulate cell death, illuminating those molecules that provide targets for agonists or antagonists designed to modulate death signaling for therapeutic purposes. The authors focus on the extrinsic system of death receptors, their regulation and function, and their abnormalities in cancer. Topics of particlar interest include resistance to apoptosis, TRAIL signaling, death receptors in embryonic development, mechanisms of caspase activation, and death receptor mutations in cancer. Additional chapters address death signaling in melanoma, synthetic retinoids and death receptors, the role of p53 in death receptor regulation, immune suppression of cancer, and combination therapy with death ligands.

Authoritative and up-to-date, Death Receptors in Cancer Therapy offers a timely compendium of cell death signaling pathways for those seeking either a basic understanding of apoptosis or the knowledge needed to develop new therapeutics that will activate or block death signaling in disease.


Contents:

Mammalian Cell Death Pathways: Intrinsic and Extrinsic
E. Robert McDonald III and Wafik S. El-Deiry

Resistance to Apoptosis in Cancer Therapy
David J. McConkey

Structures of TNF Receptors and Their Interactions With Ligands
Sarah G. Hymowitz and Abraham M. de Vos

Death Receptor Signaling in Embryonic Ectodermal Development
Preet M. Chaudhary

Adaptor Proteins in Death Receptor Signaling
Nien-Jung Chen and Wen-Chen Yeh

Caspase Activation by the Extrinsic Pathway
Xiaolu Yang

Death Signaling and Therapeutic Applications of TRAIL
Mi-Hyang Kim and Dai-Wu Seol

Death Receptor Mutations
Sug Hyung Lee, Nam Jin Yoo, and Jung Young Lee

Regulation of Death Receptors
Udo Kontny and Heinrich Kovar

Regulation of TRAIL Receptor Expression in Human Melanoma
Peter Hersey, Si Yi Zhang, and Xu Dong Zhang

Regulation of Death Receptors by Synthetic Retinoids
Shi-Yong Sun

Role of p53 in Regulation of Death Receptors
Rishu Takimoto

Proapoptotic Gene Silencing Via Methylation in Human Tumors
Tanya Tekautz, Tal Teitz, Jill M. Lahti, and Vincent J. Kidd

Regulation of Death Receptor-Induced Apoptosis by NF-kB and Interferon Signaling Pathways: Implications for Cancer Therapy
Rajani Ravi and Atul Bedi

TRAIL in Cancer Therapy
Mahaveer Swaroop Bhojani, Brian D. Ross, and Alnawaz Rehemtulla

Expression and Regulation of Death Receptors in Multiple Myeloma and Prostate Carcinoma
Subrata Ray, John G. Hissong, Marcela Oancea, and Alex Almasan

Regulation of TRAIL-Induced Apoptosis by Transcriptional Factors
Rüdiger Göke and Youhai H. Chen

Sensitizing Tumor Cells by Targeting Death Receptor Signaling Inhibitors
Christina Voelkel-Johnson

Ceramide, Ceramidase, and FasL Gene Therapy in Prostate Cancer
James S. Norris,David H. Holman, Marc L. Hyer, Alicja Bielawska, Ahmed El-Zawahry, Charles Chalfant, Charles Landen, Stephen Tomlinson, Jian-Yun Dong, Lina M. Obeid, and Yusuf Hannun

Gene Therapy Targeting Receptor-Mediated Cell Death to Cancers
Lidong Zhang and Bingliang Fang

Combination of Chemotherapy and Death Ligands in Cancer Therapy
Simone Fulda and Klaus-Michael Debatin

Index


PRODUCT DETAILS

ISBN-13: 9781617374012
Publisher: Springer (Humana Press)
Publication date: November, 2010
Pages: 388
Weight: 736g
Availability: POD
Subcategories: Oncology
Related books
From the same series

CUSTOMER REVIEWS

Average Rating 

From the reviews:

"The book is resourceful for both basic scientists and clinicians, who are interested in developing targeted therapies for cancer. … the book is a valuable tool for researchers as well as to those of us involved in teaching apoptosis to undergraduate and graduate students." (Harikrishna Nakshatri, Leukemia Research, 2005)