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Muscle Biophysics
From Molecules to Cells
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Main description:

Muscle contraction has been the focus of scientific investigation for more than two centuries, and major discoveries have changed the field over the years. Early in the twentieth century, Fenn (1924, 1923) showed that the total energy liberated during a contraction (heat + work) was increased when the muscle was allowed to shorten and perform work. The result implied that chemical reactions during contractions were load-dependent. The observation underlying the “Fenn effect” was taken to a greater extent when Hill (1938) published a pivotal study showing in details the relation between heat production and the amount of muscle shortening, providing investigators with the force-velocity relation for skeletal muscles. Subsequently, two papers paved the way for the current paradigm in the field of muscle contraction. Huxley and Niedergerke (1954), and Huxley and Hanson (1954) showed that the width of the A-bands did not change during muscle stretch or activation. Contraction, previously believed to be caused by shortening of muscle filaments, was associated with sliding of the thick and thin filaments. These studies were followed by the classic paper by Huxley (1957), in which he conceptualized for the first time the cross-bridge theory; filament sliding was driven by the cyclical interactions of myosin heads (cross-bridges) with actin. The original cross-bridge theory has been revised over the years but the basic features have remained mostly intact. It now influences studies performed with molecular motors responsible for tasks as diverse as muscle contraction, cell division and vesicle transport.


1. Chapters contributed by world leaders in their field
2. Material covers an updated, comprehensive inclusion of techniques in both cell and molecular biophysiology
3. Represents an excellent source of information for readers intending to understand the mechanics of muscle contraction

Back cover:

Muscle contraction has been the focus of scientific investigation for more than two centuries, and major discoveries have changed the field over the years. This book centers mostly on mechanical studies, dealing with force production and regulation; it gathers studies performed by scientists who have used diverse muscle techniques, and who have shaped the field of muscle contraction throughout the past years. Starting with theoretical approaches to understand myosin molecule function and energetics, this book covers experimental work performed with single molecules, and discusses results from studies investigating basic mechanisms of contraction, using (mostly in order of appearance) isolated sarcomeres, myofibrils, and fibers are presented. The last chapters summarize studies investigating the effects of acute and chronic adaptations, including weakness and muscle disease. Muscle Biophysics represents an excellent source of information for readers intending to understand the mechanics of muscle contraction, and is a fascinating collection of chapters that will hopefully stimulate young investigators to pursue research in this exciting field of research.


Chapter 1, Striated Muscles: From Molecules To Cells
D. E. Rassier

Chapter 2, Contractile Performance Of Striated Muscle
K. A. P. Edman

Chapter 3, Energy Economy In The Actomyosin Interaction: Lessons From Simple Models
S. L. Lehman

Chapter 4, A Strain-Dependency Of Myosin Off-Rate Must Be Sensitive To Frequency To Predict The B-Process Of Sinusoidal Analysis
B. M. Palmer

Chapter 5, Electron Microscopic Visualization Of The Cross-Bridge Movement Coupled With Atp Hydrolysis In Muscle Thick Filaments In Aqueous Solution, Reminiscences And Future Prospects
H. Sugi

Chapter 6, Role Of Titin In Skeletal Muscle Function And Disease
C. A. C. Ottenheijm, H. Granzier

Chapter 7, Contractile Characteristics Of Sarcomeres Arranged In Series Or Mechanically Isolated From Myofibrils
D. E. Rassier, I. Pavlov

Chapter 8, The Force-Length Relationship Of Mechanically Isolated Sarcomeres
W. Herzog, V. Joumaa, T. R. Leonard

Chapter 9, Extraction And Replacement Of The Tropomyosin-Troponin Complex In Isolated Myofibrils
B. Scellini, N. Piroddi , C. Poggesi, C. Tesi

Chapter 10, Stretch And Shortening Of Skeletal Muscles Activated Along The Ascending Limb Of The Force-Length Relation
D. E. Rassier, C. Pun

Chapter 11, Cross-Bridge Properties In Single Intact Frog Fibers Studied By Fast Stretches
B. Colombini, M. Nocella, G. Benelli, G. Cecchi, M. A. Bagni

Chapter 12, Crossbridge And Non-Crossbridge Contributions To Force In Shortening And Lengthening Muscle
K. W. Ranatunga, H. Roots, G. J. Pinniger, G. W. Offer

Chapter 13, Short-Range Mechanical Properties Of Skeletal And Cardiac Muscles
K. S. Campbell

Chapter 14, Crossbridge Mechanism(S) Examined By Temperature Perturbation Studies On Muscle
K. W. Ranatunga, M. E. Coupland

Chapter 15, Efficiency Of Cross-Bridges And Mitochondria In Mouse Cardiac Muscle
C. J. Barclay, C. Widén

Chapter 16, Mechanisms Of Skeletal Muscle Weakness
H. Westerblad, N. Place, T. Yamada

Chapter 17, Stretch-Induced Membrane Damage In Muscle:Comparison Of Wild-Type And Mdx Mice
D. G. Allen, B. Zhang, N. P. Whitehead

Chapter 18, Cellular And Whole Muscle Studies Of Activity Dependent Potentiation
B. R. Macintosh


ISBN-13: 9781461426639
Publisher: Springer (Springer New York)
Publication date: November, 2012
Pages: 366
Weight: 563g
Availability: POD
Subcategories: Biochemistry
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