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MORE ABOUT THIS BOOK
Main description:
Ghrelin, the endogenous ligand for the growth hormone secretagogue (GHS) receptor, is critical in the control of food intake and energy balance. The ghrelin receptors are now known to have important physiological properties as modulators of growth hormone release, appetite, glucose homeostasis, metabolism, immune function, neurotransmitter activity, cognitive function and neurodegeneration. Bringing all of this information together in the first comprehensive text on the topic, Ghrelin in Health and Disease provides a state-of-the-art synthesis of the latest work in this area for physicians and physician-scientists. This volume addresses the unique property of ghrelin as a modulator of function. Such a property provides potential utility for safe intervention in a wide variety of disease states. Indeed as we learn more about the basic physiology of ghrelin, the potential for treating new disease targets emerge requiring validation in the clinic. Each chapter in this volume is authored by a leading investigator in the field. The introductory chapter sets the background for the book and provides a superb overview of the relevance of ghrelin to physiology, describing how the discovery of ghrelin has prompted us to completely rethink traditional physiology. The authors conclude their chapters by critically addressing the future translational aspects of ghrelin biology and outlining what key basic research and clinical questions remain to be addressed. An invaluable resource, Ghrelin in Health and Disease distinguishes itself as the first comprehensive title covering all of the molecular and clinical issues relating to ghrelin and advancing our clinical understanding of obesity, growth, and reproductive pathogenesis.
Contents:
Preface
Roy G. Smith
Chapter 1. Ghrelin: A History of Its Discovery
Cyril Y. Bowers
G.A. Reynolds
Johannes D. Veldhuis
Chapter 2. Enzymatic Processing of Ghrelin Precursor
Masayasu Kojima
Kenji Kangawa
Chapter 3. Ghrelin's Novel Signaling in Islet b-Cells to Inhibit Insulin Secretion and Its Blockade As a Promising Strategy to Treat Type 2 Diabetes
Katsuya Dezaki
Damdindorj Boldbaatar
Tomoyuki Kurashina
Toshihiko Yada
Chapter 4. Gastric Ghrelin in the Regulation of Appetite and Metabolism
Luisa Maria Seoane
Ana Belen Crujeiras
Omar Al-Massadi
Felipe F. Casanueva
Chapter 5. Ghrelin Regulation of AMPK in the Hypothalamus and Peripheral Tissues
Miski Scerif
Blerina Kola
Marta Korbonits
Chapter 6. Ghrelin: Neuropeptide Regulator of Metabolism
Pablo J. Enriori
Zane Andrews
Michael Alexander Cowley
Chapter 7. GOAT and the Regulation of Energy and Glucose Homeostasis
Henriette Kirchner
Matthias Tschoep
Jenny Tong
Chapter 8. Ghrelin Regulation of Sleep, Circadian Clock and Body Temperature
Eva Szentirmai
Levente Kapas
Chapter 9. Ghrelin Regulation of Learning, Memory and Neurodegeneration
Tamas L. Horvath
Chapter 10. Ghrelin Antagonism: A Potential Therapeutic Target for Addictive Behavior Disorders
Elisabet Jerlhag
Emil Egecioglu
Joergen Engel
Suzanne L. Dickson
Chapter 11. Ghrelin Receptor Agonists in Cachexia of Human Aging
Ralf Nass
Michael O. Thorner
Chapter 12. Use of Ghrelin and Ghrelin Receptor Agonists in Cancer- and Chemotherapy-Induced Cachexia
Basil Burney
Jose M. Garcia
Chapter 13. Ghrelin in Cachexia Associated with End-Stage Renal Disease
Damien Ashby
Peter Choi
Stephen Bloom
Chapter 14. Ghrelin Suppression of Autoimmune Encephalomyelitis
Sachiko Miyake
Takashi Yamamura
Chapter 15. Physiological Roles of Des-Acyl Ghrelin
S.J.C.M.M. Neggers
Riccarda Granata
Ezio Ghigo
Aart J. van der Lely
PRODUCT DETAILS
Publisher: Springer (Humana Press Inc.)
Publication date: October, 2012
Pages: 315
Weight: 623g
Availability: Available
Subcategories: Biochemistry, Endocrinology, Geriatrics, Immunology, Neuroscience, Physiology
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