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MORE ABOUT THIS BOOK
Main description:
Although respiratory syncytial virus (RSV) has been a high priority for vaccine development for over 50 years now, still no vaccine is available and none has yet demonstrated sufficient promise to move to licensure. The success of RSV immune prophylaxis and the availability of ever more powerful tools to study the immune response and pathogenesis of disease, combined with the ability to construct a wide variety of vaccines using different vaccine platforms, give us grounds to believe that an RSV vaccine is within reach. This book brings together in one source what is currently known about the virus: its clinical and epidemiologic features; the host response and pathogenesis of the disease; vaccines, vaccine platforms, and treatment; and animal and tissue culture models of RSV infection. It is designed to organize the critical information relevant to RSV vaccine development, facilitate the assimilation of data, and speed progress toward producing a safe and effective vaccine.
Contents:
Part I Virology, Pathogenesis, and Clinical and Epidemiological Features of Disease
Respiratory Syncytial Virus: Virology, Reverse Genetics, and Pathogenesis of Disease
Peter L. Collins, Rachel Fearns, and Barney S. Graham
Clinical and Epidemiologic Features of Respiratory Syncytial Virus
Caroline B. Hall, Eric A. F. Simoes, and Larry J. Anderson
Influence of Respiratory Syncytial Virus Strain Differences on Pathogenesis and Immunity
Jose A. Melero and Martin L. Moore
Structure and Function of Respiratory Syncytial Virus Surface Glycoproteins
Jason S. McLellan, William C. Ray and Mark E. Peeples
Respiratory Syncytial Virus and Reactive Airway Disease
Matthew T. Lotz, Martin L. Moore, and R. Stokes Peebles, Jr.
Part II Host Response to Infection and Genetics of Disease
Human Genetics and Respiratory Syncytial Virus Disease: Current Findings and Future Approaches
Eun Hwa Choi, Hoan Jong Lee, and Stephen J. Chanock
Innate Immune Responses to Respiratory Syncytial Virus Infection
Sumanta Mukherjee and Nicholas W. Lukacs
The Adaptive Immune Response to Respiratory Syncytial Virus
Steven. M. Varga and Thomas J. Braciale
Respiratory Syncytial Virus Mechanisms to Interfere with Type 1 Interferons
Sailen Barik
Host Gene Expression and Respiratory Syncytial Virus Infection
Ralph A. Tripp, Asuncion Mejias, and Octavio Ramilo
Consequences of Immature and Senescent Immune Responses for Infection with Respiratory Syncytial Virus
Allison M.W. Malloy, Ann R. Falsey, and Tracy J. Ruckwardt
Part III Vaccine Platforms and Treatment Options
Respiratory Syncytial Virus Disease: Prevention and Treatment
Helen Y. Chu and Janet A. Englund
Live-Attenuated Respiratory Syncytial Virus Vaccines
Ruth A. Karron, Ursula J. Buchholz, and Peter L. Collins
Subunit and Virus-Like Particle Vaccine Approaches for Respiratory Syncytial Virus
Trudy G. Morrison and Edward E. Walsh
Gene-Based Vaccine Approaches for Respiratory Syncytial Virus
Rebecca J. Loomis and Philip R. Johnson
Part IV Animal and Tissue Culture Models of Infection
Bovine Model of Respiratory Syncytial Virus Infection
Geraldine Taylor
The Cotton Rat S. hispidus Model of Respiratory Syncytial Virus Infection
Marina S. Boukhvalova and Jorge C.G. Blanco
The Mouse Model of Respiratory Syncytial Virus Disease
Peter J. Openshaw
Human Airway Epithelial Cell Cultures for Modeling Respiratory Syncytial Virus Infection
Raymond J. Pickles
Part V Conclusions
Challenges and Opportunities for Respiratory Syncytial Virus Vaccines
Barney S. Graham and Larry J. Anderson
PRODUCT DETAILS
Publisher: Springer (Springer-Verlag Berlin and Heidelberg GmbH & Co. K)
Publication date: January, 2014
Pages: 350
Weight: 7568g
Availability: Available
Subcategories: Immunology, Infectious Diseases, Microbiology, Paediatrics and Neonatal, Pharmacology, Respiratory Medicine
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