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MORE ABOUT THIS BOOK
Main description:
Legionnaires' disease, a potentially fatal type of pneumonia primarily affecting elderly and immuno-compromised persons, is caused by the ubiquitous environmental bacterium Legionella pneumophila. This book offers authoritative reviews of different facets of its virulence, focusing on comparative phagocyte infection, virulence gene regulation, biochemical functions of effector proteins and cellular pathogen-host interactions, as well as host responses and immunity to L. pneumophila. Taken together, the contributions in this compilation provide a state-of-the-art overview of current insights into the molecular pathogenesis of the opportunistic and potentially fatal pathogen L. pneumophila.
Contents:
From amoeba to macrophages: exploring the molecular mechanisms of Legionella infection in both hosts
Pedro Escoll, Monica Rolando, Laura Gomez-Valero and Carmen Buchrieser
The Legionella pneumophila two-component regulatory systems that participate in the regulation of Icm/Dot effectors
Gil Segal
Facets of small RNA-mediated regulation in Legionella pneumophila
Hana Trigui, Nilmini Mendis, Laam Li, Mariam Saad and Sebastien P. Faucher
Type II secretion and Legionella virulence
Nicholas P. Cianciotto
Effector translocation by the Legionella Icm/Dot type IV secretion system
Jiazhang Qiu and Zhao-Qing Luo
Modulation of small GTPases by Legionella
Roger S. Goody and Aymelt Itzen
Host lipidation: A mechanism for spatial regulation of Legionella effectors
Stanimir S. Ivanov and Craig Roy
Phosphoinositides and the Legionella pathogen vacuole
Ina Haneburger and Hubert Hilbi
Legionella phospholipases implicated in virulence
Katja Kuhle and Antje Flieger
Cytotoxic glucosyltransferases of Legionella pneumophila
Yury Belyi, Thomas Jank and Klaus Aktories
Modulation of the ubiquitination machinery by Legionella
Andree Hubber, Tomoko Kubori and Hiroki Nagai
Host signal transduction and protein kinases implicated in Legionella infection
Andrew D. Hempstead and Ralph R. Isberg
Mouse models of Legionnaires disease
Andrew S Brown, Ian R van Driel and Elizabeth L Hartland
PRODUCT DETAILS
Publisher: Springer (Springer-Verlag Berlin and Heidelberg GmbH & Co. K)
Publication date: October, 2013
Pages: 280
Weight: 5856g
Availability: Available
Subcategories: General Issues, Immunology, Infectious Diseases, Microbiology
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