(To see other currencies, click on price)
MORE ABOUT THIS BOOK
Main description:
From humble beginnings over 25 years ago as a lipid kinase activity associated with certain oncoproteins, PI3K (phosphoinositide 3-kinase) has been catapulted to the forefront of drug development in cancer, immunity and thrombosis, with the first clinical trials of PI3K pathway inhibitors now in progress. Here we give a brief overview of some key discoveries in the PI3K area and their impact, and include thoughts on the current state of the field, and where it could go from here
Contents:
Contents volume 1:
PI3K Book Introduction.- PDK1: The major transducer of PI 3-kinase actions.- Protein Kinase B (PKB/Akt), a key mediator of the PI3K signaling pathway.- Regulatory subunity of class IA PI3K.- The Regulation of Class IA PI 3-kinases by Inter-Subunit Interactions.- Phosphoinositide signalling pathways in metabolic regulation.- Role of RAS in the regulation of PI 3-kinase.- More than just kinases: the scaffolding function of PI3K.- PI3K signalling in neutrophils.- PI 3-kinase p110beta Regulation of Platelet Integrin alphaIIbbeta3.- PI3Ks in lymphocyte signaling and development.- The neurodevelopmental implication of PI3K signaling.- PI3kinase regulation of skeletal muscle hypertrophy and atrophy.- Taking PI3Kdelta and PI3Kgamma one step ahead - Dual active PI3Kdelta/gamma inhibotrs for the treatment of immune -mediated inflammatory diseases.- Subject index
Contents of sister volume 2:
PI3K - From the bench to the clinic and back.- Oncogenetic mutations of PIK3CA in human cancers.- Structural effects of oncogenic PI3Kalpha mutations.- Comparing the roles of the p110alpha and p110beta isoforms of PI3K in signaling and cancer.- Phophatidylinositol 3-kinase (PI3K): the oncoprotein.- AKT Signaling in Physiology and Disease.- Faithfull modeling of PTEN loss driven diseases in the mouse.- PI3K as a target for therapy in haematological malignancies.- Clinical Development of Phosphatidylinositol-3 Kinase Pathway Inhibitors.- From the bench to the bed side: PI3K pathway inhibitors in clinical development.- New Inhibitors of the PI3K-Akt-mTOR Pathway: Insights into mTOR Signaling From a New Generation of Tor Kinase Domain Inhibitors (TORKinibs).- Small molecule inhibitors of the PI3-kinase family.- Targeting the RTK-PI3K-mTOR axis in malignant glioma: overcoming resistance.- Subject index
PRODUCT DETAILS
Publisher: Springer (Springer-Verlag Berlin and Heidelberg GmbH & Co. K)
Publication date: October, 2010
Pages: 318
Weight: 705g
Availability: Available
Subcategories: General Issues, Oncology, Physiology
Publisher recommends
Christian Rommel
From the same series
Eric Vivier
Kevin V. Morris
Esteban Domingo
Eric Vivier
Tomohiro Kurosaki
Christian Munz
Christian Munz
Michael G. Katze
Bryan R. Cullen
David S. Goodsell
G. Singh Chhatwal
Ralf Bartenschlager
Ellen Heber-Katz
Andreas Rummel
Juan J. Lafaille
Thomas E. Shenk
Ben Adler
Michael B. A. Oldstone
Friedrich Koch-Nolte
Marco Falasca
Michael B. A. Oldstone
Benhur Lee
Freddy Radtke
Klaus Aktories
Jean Langhorne
Michael B. A. Oldstone
Jeremy Nuttall
Robert N. Eisenman
Z F Fu
Peter K. Vogt
Tatsuji Nomura
Wilfried Ellmeier
Marc Daeron
H. Koprowski
Hilary Koprowski
Simon Fillatreau
G. Balakrish Nair
Harris G. Fienberg
Michael B. A. Oldstone
R.M.E. Parkhouse
Lars B. Olding
Charles L. Sawyers
Cornelis Murre
Nicholas Mantis
Pamela A. Kozlowski
Charles E. Samuel
Larry J. Anderson
Kenneth Palmer
Marcel B.M. Teunissen
Rudolf Valenta
M.B.A. Oldstone
Thomas Boehm
Cesare Montecucco
Michael B.A. Oldstone
Hubert Hilbi
Hilary Koprowski
Hung Y. Fan
Walter Doerfler
Polly Roy
Michael Karin
Bryan R. Cullen
Glenn Dranoff
Rafi Ahmed
Jurgen A.. Richt
Ulrich Dobrindt
Ellen Heber-Katz
G. Singh Chhatwal
Ralf Bartenschlager
Peter K. Vogt
Robert L. Coffman
Michael G. Katze
Harald Stenmark
Andreas Rummel
Christian Rommel
Fritz Melchers
H. Koprowski
Didier Trono
Uwe Gross
Christian Rommel
M. Celeste Simon
John E. Johnson
K. Takada
Ellen Heber-Katz
C. Schmaljohn
Axel Rethwilm
Jerry L. Workman
Louis B. Justement
Marco Falasca
P.K. Vogt
Michael N. Hall
M.B.A. Oldstone
K. Hirai
Eric Vivier
Allison Abendroth
Oystein Bruserud
Carolyn Wilson
Freddy Radtke
Benhur Lee
Klaus Aktories
Harald Zur Hausen
J.S. Mackenzie
Adrienne E. Clarke
Stefan H.E. Kaufmann
Bernhard Fleischer
Michael Potter
H. Koprowski
H. Koprowski
Rolf Jessberger
Charles L. Sawyers
Chihiro Sasakawa
Vojo Deretic
Alan L. Rothman
Marco Colonna
H. Koprowski
Karl Maramorosch
H. Koprowski
Eckhard R. Podack
Paul Spearman
Takashi Saito
H. Koprowski
W. Doerfler
Michael Loos
H. Koprowski
Daniel Kolakofsky
H. Koprowski
H. Koprowski
Michael Potter
Kenneth I. Berns
H. Koprowski
J. Lindsay Whitton
Fritz Melchers
Nicholas Mantis
Cornelis Murre
Pamela Kozlowski
Klaus Aktories
Fritz Melchers
O. Haller
Peter K. Vogt
Norman L. Letvin
Dan R. Littman
Michael Potter
Robert F. Ramig
Gillian M. Griffiths
H. Koprowski
David Gray
T.A. Trautner
Michael B. A. Oldstone
Jiri Mestecky
Richard W. Moyer
Fritz Melchers
Michael B. A. Oldstone
Guido Kroemer
Hilary Koprowski
H. Koprowski
Peter K. Vogt
Bruce W. Chesebro
Charles J. Parker
P.J. Sansonetti
H. Koprowski
Rolf Knippers
Walter Doerfler
Klaus Jann
Virginia L. Miller
Marie H. Kosco-Vilbois
Peggy J. Farnham
Peter M Schlag
Thomas M. Shinnick
Hilary Koprowski
Anthony J. Pawson
Walter Doerfler
Peter K. Vogt
Klaus Jann
Vincent R. Racaniello
Nicholas Muzyczka
Mark Bothwell
Volker Ter Meulen
Jean-Pierre Kraehenbuhl
Michael B. A. Oldstone
P.H. Hofschneider
Steinunn Baekkeskov
H. Koprowski
F. Melchers
Garnett Kelsoe
Arthur E. Frankel
Michael B. A. Oldstone
Michael B. A. Oldstone
Peter Sarnow
Hermann Wagner
Rudolf Rott
H.L. Robinson
Fritz Melchers
John J. Holland
Jeffrey L. Dangl
Richard W. Compans
Charles Mackay
Beat A. Imhof
H. Koprowski
P.K. Vogt
H. Koprowski
P.A. Bachmann
P.K. Vogt
W. Doerfler
H. Koprowski
P.K. Vogt
Leslie Hudson
Michael Potter
Fritz Melchers
Michael B. A. Oldstone
William S. Mason
Peter K. Vogt
H. Koprowski
P.K. Vogt
Melvin J. Bosma
James K. McDougall
Stefan H.E. Kaufmann
N.J. Dimmock
Peter K. Vogt
Michael B. A. Oldstone
Walter Orenstein
Hans-Georg Krausslich
Fritz Melchers
Christa E. Muller-Sieburg
John D. Lambris
Siamon Gordon
Hermann Wagner
H. Koprowski
Hilary Koprowski
D.B. Willis
Walter Doerfler
A. J. Shatkin
P.K. Vogt
Christopher J. Paige
Michael Potter
Michael B. A. Oldstone
W. Doerfler
Henry C. Wu
Hermann Wagner
Michael B. A. Oldstone
H. Koprowski
H. Koprowski
H. Koprowski
H. Koprowski
Barry T. Rouse
H. Koprowski
Fritz Melchers
H. Koprowski
H. Koprowski
H. Koprowski
H. Koprowski
Charles E. Samuel
F. Melchers
H. Koprowski
H. Koprowski
H. Koprowski
Hans-Dieter Klenk
David W. Weiss
U.H. Koszinowski
Ernst-L. Winnacker
Steven Tracy
L. Du Pasquier
Michael B. Kastan
H. Wagner
Fritz Melchers
Ursula Gunthert
T. Ulf Westblom
P.K. Vogt
Lena Claesson-Welsh
C.H. Hagedorn
Stanley B. Prusiner
Wolfgang Baumeister
Bruce Beutler
Louis B. Justement
Ursula Gunthert
Marcel B.M. Teunissen
Rudolf Valenta
Michael Karin
Glenn Dranoff
Rafi Ahmed
Inger Helene Madshus
Lyubomir T. Vassilev
Martin L. Privalsky
Walter Doerfler
Alexander Steinkasserer
Dennis R. Burton
T.M. Koehler
Jurgen A.. Richt
Walter Doerfler
David A. Harris
Yoshihiro Kawaoka
Paula M. Pitha
Branch D. Moody
Scott Dessain
James L. van Etten
Michael B. A. Oldstone
Tony Romeo
Rafi Ahmed
Steven Tracy
Harald Zur Hausen
Michael B. A. Oldstone
Thomas E. Lane
Tasuku Honjo
Marianne Manchester
Walter Doerfler
Diane E. Griffin
Mark Marsh
Alexander V. Karasev
Dorian McGavern
B. W. J. Mahy
Riccardo Dalla-Favera
Sanjeev Krishna
Patrice Boquet
Klaus Aktories
Luis Enjuanes
Christian Rommel
M. Celeste Simon
John E. Johnson
Oystein Bruserud
Allison Abendroth
Peter E. Lipsky
Walter Doerfler
Stanley A. Plotkin
John L. Casey
William M. Shafer
Esteban Domingo
Eric Vivier
Takashi Saito
Paul Spearman
Chihiro Sasakawa
Alan L. Rothman
Vojo Deretic
Walter Orenstein
Dorian McGavern
Alexander V. Karasev
Harald Zur Hausen
Michael B. A. Oldstone
Michael B. A. Oldstone
James L. van Etten
Marianne Manchester
Thomas E. Shenk
Tatsuji Nomura
Tony Romeo
Steven Tracy
Peter K. Vogt
Scott Dessain
Paula M. Pitha
D.B. Moody
Peter K. Vogt
Robert A. Weiss
Rafi Ahmed
Stanley A. Plotkin
Tasuku Honjo
Walter Doerfler
William M. Shafer
John L. Casey
Peter E. Lipsky
Thomas E. Lane
Robert N. Eisenman