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MORE ABOUT THIS BOOK
Main description:
This volume gathers the latest exciting findings on ADP-ribosylation from renowned experts in the field. It includes ten chapters, organized into the following three thematic sections:
* Evolution and detection of endogenous ADP-ribosylation
* ADP-ribosylation by the ARTC family of ADP-ribosyltransferases (R-S-E ARTs)
* ADP-ribosylation by the ARTD family of ADP-ribosyltransferases (H-Y-E ARTs)
The book will provide readers a better understanding of ADP-ribosylating toxins and their endogenous relatives. This provides a basis for developing novel toxin-neutralizing drugs and drugs targeting endogenous ADP-ribosyltransferase relatives.
Contents:
Part I: Evolution and Detection of Endogenous ADP-Ribosylation
The natural history of ADP-ribosyltransferases and the ADP ribosylation system
L. Aravind, Dapeng Zhang, Robson F. de Souza, Swadha Anand and Lakshminarayan M. Iyer
Identification and Analysis of ADP-ribosylated Proteins
Friedrich Haag and Friedrich Buck
Part II: ADP-Ribosylation by ARTCs (R-S-E ARTs)
Photorhabdus luminescens toxins TccC3 and TccC5: Insecticidal ADP-ribosyltransferases that modify threonine and glutamine
Klaus Aktories, Gudula Schmidt and Alexander E. Lang
Reaction mechanism of mono-ADP-ribosyltransferase based on structures of the complex of enzyme and substrate protein
Hideaki Tsuge, Toshiharu Tsurumura
Regulation of nitrogenase by reversible mono-ADP-ribosylation
Vivian R. Moure, Flavia F. Costa, Leonardo M. Cruz, Fabio O. Pedrosa, Emanuel M. Souza, Xiao-Dan Li, Fritz Winkler and Luciano F. Huergo
ADP-ribosylation of P2X7: a matter of life and death for regulatory T cells and natural killer T cells
Bjoern Rissiek, Friedrich Haag, Olivier Boyer, Friedrich Koch-Nolte, Sahil Adriouch
Pierisins and CARP-1: ADP-ribosylation of DNA by ARTCs in butterflies and shellfish
Tsuyoshi Nakano, Azusa Takahashi-Nakaguchi, Masafumi Yamamoto, and Masahiko Watanabe
Part III: ADP-Ribosylation by ARTDs (H-Y-E ARTs)
Comparative structural analysis of the putative mono-ADP-ribosyltransferases of the ARTD/PARP family
Ana Filipa Pinto and Herwig Schuler
Function and regulation of the mono-ADP-ribosyltransferase ARTD10
Max Kaufmann, Karla L. H. Feijs, and Bernhard Luscher
Regulation of nucleocytoplasmic transport by ADP-ribosylation: the emerging role of karyopherin- 1 mono-ADP-ribosylation by ARTD15
Maria Di Girolamo
PRODUCT DETAILS
Publisher: Springer (Springer International Publishing AG)
Publication date: November, 2014
Pages: 200
Weight: 4616g
Availability: Available
Subcategories: Immunology, Microbiology, Pharmacology
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