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MORE ABOUT THIS BOOK
Main description:
This volume thoroughly covers HIV-1 antiretrovirals currently in clinical use, together with their advantages and limitations. HIV-1 inhibitor resistance is discussed in detail, and critical assessments as to what will be required of future antiretrovirals in order to halt viral replication, reduce viral resistance, and alter the state of viral latency are presented. Experts at the forefront of HIV-1 research provide overviews of approaches from the fields of virology, chemical biology and structural biology for obtaining small molecule inhibitors that target viral regulatory and structural components at multiple points in the viral lifecycle. The individual chapters will appeal to scientists and clinicians alike.
Contents:
HIV Therapy Looking Towards the Future
David Looney, Ariel Ma, and Scott Johns
Computational challenges of structure-based approaches applied to HIV
Stefano Forli and Arthur J. Olson
Nucleocapsid Protein: A Desirable Target For Future Therapies Against HIV-1
Mattia Mori, Lesia Kovalenko, Sebastien Lyonnais, Danny Antaki, Bruce E. Torbett, Maurizio Botta, Gilles Mirambeau, and Yves Mely
HIV-1 integrase multimerization as a therapeutic target
Lei Feng, Ross Larue, Jacques J. Kessl, and Mamuka Kvaratskhelia
Targeting HIV transcription: The quest for a functional cure
Guillaume Mousseau, Sonia Mediouni, and Susana T. Valente
Targeting the HIV RNA Genome: High-Hanging Fruit Only Needs a Longer Ladder
Stuart F.J. Le Grice
HIV-1 Gag: An Emerging Target for Antiretroviral Therapy
Philip R. Tedbury and Eric O. Freed
The Triple Threat of HIV-1 Protease Inhibitors
Marc Potempa, Sook-Kyung Lee, Richard Wolfenden, and Ronald Swanstrom
Illustrations of the HIV Life Cycle
David S. Goodsell
PRODUCT DETAILS
Publisher: Springer (Springer International Publishing AG)
Publication date: May, 2015
Pages: 260
Weight: 5207g
Availability: Available
Subcategories: Infectious Diseases, Microbiology, Pharmacology
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