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The Future of HIV-1 Therapeutics
Resistance Is Futile?
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Main description:

This volume thoroughly covers HIV-1 antiretrovirals currently in clinical use, together with their advantages and limitations. HIV-1 inhibitor resistance is discussed in detail, and critical assessments as to what will be required of future antiretrovirals in order to halt viral replication, reduce viral resistance, and alter the state of viral latency are presented. Experts at the forefront of HIV-1 research provide overviews of approaches from the fields of virology, chemical biology and structural biology for obtaining small molecule inhibitors that target viral regulatory and structural components at multiple points in the viral lifecycle. The individual chapters will appeal to scientists and clinicians alike.


Feature:

Highlights the identification and evaluation of antiretrovirals that may be less prone in selecting for HIV-1 resistance

Covers recent advances in the identification and function of small molecule inhibitors that target novel HIV-1 regulatory and structural components to disrupt replication and alter the state of viral latency

Offers up-to-date information for virologists, infectious disease specialists, and chemical biologists on HIV-1 antiretrovirals currently in use


Contents:

HIV Therapy ­ Looking Towards the Future

David Looney, Ariel Ma, and Scott Johns

 

Computational challenges of structure-based approaches applied to HIV

Stefano Forli and Arthur J. Olson

 

Nucleocapsid Protein: A Desirable Target For Future Therapies Against HIV-1

Mattia Mori, Lesia Kovalenko, Sébastien Lyonnais, Danny Antaki, Bruce E. Torbett, Maurizio Botta, Gilles Mirambeau, and Yves Mély

 

HIV-1 integrase multimerization as a therapeutic target

Lei Feng, Ross Larue, Jacques J. Kessl, and Mamuka Kvaratskhelia

 

Targeting HIV transcription: The quest for a functional cure

Guillaume Mousseau, Sonia Mediouni, and Susana T. Valente

 

Targeting the HIV RNA Genome: High-Hanging Fruit Only Needs a Longer Ladder

Stuart F.J. Le Grice

 

HIV-1 Gag: An Emerging Target for Antiretroviral Therapy

Philip R. Tedbury and Eric O. Freed

 

The Triple Threat of HIV-1 Protease Inhibitors

Marc Potempa, Sook-Kyung Lee, Richard Wolfenden, and Ronald Swanstrom

 

Illustrations of the HIV Life Cycle

David S. Goodsell


PRODUCT DETAILS

ISBN-13: 9783319185170
Publisher: Springer (Springer International Publishing)
Publication date: May, 2015
Pages: 260
Weight: 561g
Availability: POD
Subcategories: Infectious Diseases, Microbiology, Pharmacology
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CUSTOMER REVIEWS

Average Rating 

“The book does a fantastic job of addressing new approaches to inhibit HIV-1. … this is a useful book that can be used by researchers, HIV clinicians, and medicinal chemists interested in investigating new molecules for the treatment of HIV-1. It addresses novel areas that have no chemical entities that are FDA approved. There are no books that compete with this one.” (Christopher J. Destache, Doody's Book Reviews, September, 2015)