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Studies on Cardiovascular Disorders
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Cutting-edge research Leading scientists in the field

Back cover:

This collection of articles on oxidative stress in clinical practice surveys essential current research in what is a rapidly evolving field. As well as giving the reader a mechanistic overview of how oxidative stress affects cardiovascular disease, it analyzes the potential of a number of therapeutic options that target these pathways. Understanding the complexity of the cellular redox system could lead to the development of better targeted interventions that facilitate patient recovery. Even as large-scale clinical trials of so-called ‘simple’ antioxidant approaches such as vitamins C and E show that significant benefits for cardiovascular patients remain elusive, Studies on Cardiovascular Disorders demonstrates that such approaches are too simplistic.

Beginning with a summary of redox signaling models that could induce the progression of redox-associated cardiovascular disorders, the volume moves on to examine redox-mediated protein modification under physiological and pathophysiological conditions. It provides an outline of the signaling pathways in cardiovascular development during embryogenesis, and what impact these might have in the differentiation process of resident cardiac and blastocyst derived stem cells. Further chapters detail our current knowledge of the influence the sensory nervous system exerts on the cardiovascular system, and the paradoxical role of mitochondria-derived ROS in cardiac protection. In all, almost 30 contributions cover issues as diverse as the antioxidant properties of statins in the heart and the oxidative risk factors for cardiovascular disease in women. A range of medical practitioners will find the contents of Studies on Cardiovascular Disorders provides illuminating insight into the Janus-faced role of ROS in the cardiovascular system.



Contributor’s List


1) The evolving concept of oxidative stress
Denise de Castro Fernandes, Diego Bonatto, Francisco R. M. Laurindo

2) Mechanisms of redox signaling in cardiovascular disease
Rebecca L. Charles, Joseph R. Burgoyne and Philip Eaton

3) Reactive oxygen and nitrogen species in cardiovascular differentiation of stem cells
Heinrich Sauer and Maria Wartenberg§

4) Reactive Oxygen Species (ROS) and the sensory neurovascular component
Rabea Graepel BSc, Jennifer Victoria Bodkin BSc, MRes, & Susan Diana Brain BSc, PhD

5) Mitochondrial Reactive Oxygen Species in Myocardial Pre- and Post-Conditioning
Ariel R. Cardoso, Bruno B. Queliconi* and Alicia J. Kowaltowski

6) Coenzyme Q9/Q10 and Healthy Heart
Samarjit Das, Somak Das and Dipak K. Das

7) Oxidative and proteolytic stress in homocysteine associated cardiovascular diseases
Karni S. Moshal, Munish Kumar, Neetu Tyagi, Paras Kumar Mishra, Saumi Kundu, Suresh C. Tyagi

8) Functional studies of NADPH oxidases in human vasculature
Tomasz J Guzik

9) Relationship of the CYBA gene polymorphisms with oxidative stress and cardiovascular risk
Guillermo Zalba, PhD and Javier Díez, MD, PhD

10) Redox-related genetic markers of cardiovascular diseases
Christian Delles, MD, and Anna F. Dominiczak, MD

11) NADPH oxidases and blood-brain barrier dysfunction in stroke
Timo Kahles, MD, Sabine Heumüller and Ralf P. Brandes, MD

12) Smoking-Induced Oxidative Stress in the Pathogenesis of Cardiovascular Diseases
David Bernhard PhD

13) Oxidative Stress in Vascular Aging
Anna Csiszar, MD, PhD and Zoltan Ungvari, MD, PhD

14) Oxidative Stress and Cardiovascular Disease in Diabetes Mellitus
Divya Gupta, Kathy K. Griendling and W. Robert Taylor

15) Reactive Oxygen Species, Oxidative Stress and Hypertension
Rhian M Touyz MD, PhD, Andreia Chignalia, MSc, Mona Sedeek PhD

16) Peripartum cardiomyopathy: Role of STAT-3 and reactive oxygen species
Denise Hilfiker-Kleiner, PhD, Arash Haghikia, MD, andAndres Hilfiker, PhD

17) Oxidative stress and inflammation after coronary angiography
Raymond Farah MD

18) Oxidative Stress in Cardiac Transplantation
Galen M. Pieper, Ph.D. and Ashwani K. Khanna, Ph.D

19) Oxidative Stress and Atrial Fibrillation
Ali A. Sovari and Samuel C. Dudley, Jr.

20) Oxidative stress and the anti-oxidative capacity in myocardial infarction
Yao Sun, MD, Ph.D.

21) Oxidative Stress and Redox Signalling in Cardiac Remodelling
Min Zhang MD, PhD, Alex Sirker MRCP and Ajay M Shah MD, FmedSci

22) Oxidative Stress and Cardiovascular Fibrosis
Subramanian Pennathur, Louise Hecker, and Victor J. Thannickal

23) Oxidative Risk Factors for Cardiovascular Disease in Women
M. Gago-Dominguez, Xuejuan Jiang, J. Esteban Castelao

24) Protective effects of food on cardiovascular diseases
Alfonso Giovane, Biol.D., Ph.D., and Claudio Napoli, M.D., Ph.D., MBEth.

25) Novel Synthetic Antioxidants and Nitrated Lipids: From Physiology to Therapeutic Implications
Gloria V. López , PhD and Homero Rubbo, PhD

26) Thioredoxin in the cardiovascular system – towards a thioredoxin-based anti-oxidative therapy
Bradford C. Berk

27) The protective effect of melatonin on the heart
Amanda Lochner

28) Exercise Induced cardioprotection: Overview with an emphasis on the role of anti-oxidants
Karyn L. Hamilton and John C. Quindry

29) Antioxidative properties of statins in the heart
Oliver Adam MD, Ulrich Laufs MD


ISBN-13: 9781617797071
Publisher: Springer (Humana Press)
Publication date: November, 2012
Pages: 604
Weight: 920g
Availability: POD
Subcategories: Cardiovascular Medicine
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Average Rating 

From the reviews:

“This is a collection of articles that provides insight into the evolving field of oxidative stress. … It is intended for students, physicians in training, clinicians, and cardiovascular researchers interested in oxidative stress. … This collection of articles with color diagrams provides a unique, well-organized, and clinically relevant resource on a vast range of topics relating to oxidative stress. This book will be a solid resource in this rapidly changing field.” (Paul Michael, Doody’s Review Service, February, 2011)