Main description:

There is a widespread consensus that use of antioxidants as a therapeutic approach may counteract free radical mediated pathologies. However, the role of antioxidants in normal physiology and redox signaling is still in its infancy. Since oxidative stress is related to various diseases and pathologies, scientists are eager to study the disease in humans, but it is not always ethical to study all the aspects of the disease in humans. Thus, it becomes mandatory to study the disease process and the mechanisms behind it through experimental models which generally involve animals, in vitro/cell culture studies, primates and even humans to a certain extent. Studies on Experimental Models contains data on the experimental models or review of such models of oxidative stress in various diseases. It is structured into six sections, which are as follows: diabetes, cardiovascular, neurology, ocular diseases, toxicology/environmental and in vitro/tissue culture. Each section presents a sketch of models in humans, animals and in vitro methods. Taken together, they comprise a valuable reference for basic and clinical scientists, one aimed at contributing to the advancement of oxidative stress research using appropriate animal models.

Contents:

DIABETES

Role of Oxidative Stress and Targeted Antioxidant Therapies in Experimental Models of Diabetic Complications

Judy B. de Hann, Karin A. Jandeleit-Dahm, and Terri J. Allen

Experimental Models of Oxidative Stress Related to Cardiovascular Diseases and Diabetes

Maria Dolores Mesa, Concepcion M. Aguilera, and Angel Gil

CARDIOVASCULAR

Arachidonic Acid Metabolism and Lipid Peroxidation in Stroke: Alpha-tocotrienol as a Unique Therapeutic Agent

Cameron Rink, Savita Khanna, and Chandan Sen

Assessment of Oxidative Stress in the Brain of Spontaneously Hypertensive Rat and Stroke-Prone Spontaneously Hypertensive Rat Using by Electron Spin Resonance Spectroscopy

Fumihiko Yoshino, Kyo Kobayashi, and Masaichi-Chang-il Lee

Small Heat Shock Proteins and Doxorubicin-induced Oxidative Stress in The Heart

Karthikeyan Krishnamurthy, Ragu Kanagasabai, Lawrence J. Druhan, and Govindasamy Ilangovan

Oxidative Stress in Cardiovascular Disease: Potential Biomarkers and Their Measurements

Subhendu Mukherjee and Dipak K. Das

In vivo Imaging of Antioxidant Effects on NF-kappaB Activity in Reporter Mice

Ingvild Paur, Harald Carlsen, and Rune Blomhoff

NEUROLOGY

MPTP and Oxidative Stress: It's Complicated!

V. Jackson-Lewis, C. Vives-Bauza, M.A. Tocilescu, R. DeVries, and S. Przedborski

Oxidative Stress in Alzheimers Disease: A Critical Appraisal of the Causes and the Consequences

Jaewon chang, Sandra Siedlak, Paula Moreira, Akihiko Nunomura, Rudy J. Castellani, Mark A. Smith, Xiongwei Zhu, George Perry, and Gemma Casadesus

Retinal Disturbances in Patients and Animal Models with Huntington's, Parkinson's and Alzheimer's Disease

C. Santano M. Perez de Lara Pintor

Stress Gene Deregulation in Alzheimer Peripheral Blood Mononuclear Cells

Olivier C. Maes, Howard M. Chertkow, Eugenia Wang, and Hyman M. Schipper

The Use of Gpx4 Knockout Mice and Transgenic Mice to Study the Roles of Lipid Peroxidation in Diseases and Aging

Qitao Ran and Hanyu Liang

An Experimental Model of Myocardial and Cerebral Global Ischemia and Reperfusion

Lars Wiklund and Samar Basu

OCULAR DISEASES

Neovascular Models of the Rabbit Eye Induced by Lipid Hydroperoxide

Takako Nakanishi, Toshihiko Udea, Kazushi Tamai, Shinichi Iwai, and Donald Armstrong

Purinergic Signaling Involved in the Volume Regulation of Glial Cells in the Rat Retina: Alteration in Experimental Diabetes

Andreas Bringmann

TOXICOLOGY / ENVIRONMENTAL

Helicobacter Pylori-induced Oxidative stress and Inflammation

Hyeyoung Kim and Young-Joon Surh

Experimental Models for Ionizing Radiation Research

Kristin Fabre, William DeGraff, John A. Cook, Murali C. Krishna, and James B. Mitchell

Experimental Models to Study Cigarette Smoke-Induced Oxidative Stress In Vitro and In Vivo in Pre-Clinical Models, and in Smokers and Patients with Airways Disease

Hongwei Yao and Irfan Rahman

Exhaled Breath Condensate Biomarkers of Airway Inflammation and Oxidative Stress in COPD

Paolo Montuschi

Induction of Oxidative Stress by Iron/Ascorbate in Isolated Mitochondria and by UV Irradiation in Human Skin

Ingrid Wiswedel, Wolfgang Augustin, Sven Quist, Harald Gollnick, and Andreas Gardemann

Carbon Tetrachloride Induced Hepatotoxicity: A Classical Model of Lipid Peroxidation and Oxidative Stress

Samar Basu

Enhanced Urinary Excretion of Lipid Metabolites Following Exposer to Structurally Diverse Toxicants: A Unique Experimental Model for the Assessment of Oxidative Stress

Francis C. Lau, Manashi Bagchi, Shirley Zafra-Stone and Debasis Bagchi

Oxidative Stress in Animal Models with Special Reference to Experimental Porcine Endotoxemia

Miclos Lipcsey, Mats Eriksson, and Samar Basu

Models and Approaches for the Study of Reactive Oxygen Species Generation and Activities in Contracting Sketetal Muscle

Malcolm Jackson

Exercise as a Model to Study Interactions Between Oxidative Stress and Inflammation

C. Yfanti, S. Nielsen, C Scheele, and B.K. Pedersen

Excercise as a Model to Study Oxidative Stress

Mari Carmen Gomez-Cabrera, Fabian Sanchis-Gomar, Vladimir Essau Martinez-Bello, Sandra Ibanez-Sania, Ana Lunia Nascimento, Li Li Ji, and Jose Vina

IN VITRO/TISSUE CULTURE

Models of Mitochondrial Oxidative Stress

Enrique Cadenas and Alberto Boveris

Protection of Oxidant-Induced Neuronal Cells Injury by A Unique Cruciferous Nutraceutical

Zhenquan Jia, Soumya Saha, Hong Zhu, Yunbo Li, and Hara P. Misra

Oxidatively Generated Damage to DNA and Biomarkers

Jean Cadet, Thierry Douki, and Jean-Luc Ravanat

Measuring Oxidative Stress in Cell Cultures, Animals and Humans- Analysis and Validation of Oxidatively Damaged DNA

Hanna L. Karlsson and Lennart Moeller

The Roles of cAMP and G Protein Signaling in Oxidative Stress-Induced Cardiovascular Dysfunction

Soumya Saha, Zhenquan Jia, Dongmin Liu, and Hara P. Misra

Cellular and Chemical Assays for Discovery of Novel Antioxidants in Marine Organisms

Tim Hofer, Tonje Engevik Eriksen, Espen Hansen, Ingrid Varmedal, Ida-Johanne Jensen, Jeanette Hammer-Andersen, and Ragnar Ludvig Olsen

Arsenic-Induced Oxidative Stress: Evidence on In Vitro Models of Cardiovascular, Diabetes Mellitus Type 2 and Neurodegenerative Disorders

Ruben Ruiz-Ramos, Patricia Ostrosky-Wegman, and Mariano E. Cebrian