Main description:

The role of reactive oxygen species (ROS) in the cardiovascular system is Jan- faced. Whereas low concentrations of ROS are involved in variety of physiological signalling events, oxidative stress resulting from deregulated overproduction of ROS and/or impaired antioxidant defences contributes to cardiovascular disease. The actions of ROS in the cardiovascular system are a fascinating topic, not only for the basic science researcher but also for the clinician who is interested in seeking new therapies for his patients suffering from cardiovascular disease. The current book provides a comprehensive overview of the molecular mechanisms and pathoph- iological settings in which chronic and detrimental oxidative stress arises within the heart and vasculature. The book also considers currently discussed strategies in avoiding chronic redox stress resulting from exposure to risk factors or various cardiovascular interventions. The series starts with an overview by Denise de Castro Fernandes, Diego Bonatto and Francisco Laurindo of redox signaling models that could underlie the dev- opment of redox-associated cardiovascular disorders.
The interactions of proteins within signalling cascades with ROS and the regulation of such interactions by the anti-oxidative capacity of the cell are discussed. Rebecca Charles, Joseph Burgoyne and Philip Eaton report on redox-mediated modi cations of proteins under ph- iological and pathophysiological conditions and the variety of post-translational oxidative modi cations that explain redox sensing and signal transduction by proteins at the molecular level. ROS are generated during embryogenesis and may be involved in the proper development of the cardiovascular system.

Contents:

Preface

Contributor's List

Chapters:

1) The evolving concept of oxidative stress
Denise de Castro Fernandes, Diego Bonatto, Francisco R. M. Laurindo

2) Mechanisms of redox signaling in cardiovascular disease
Rebecca L. Charles, Joseph R. Burgoyne and Philip Eaton

3) Reactive oxygen and nitrogen species in cardiovascular differentiation of stem cells
Heinrich Sauer and Maria Wartenberg

4) Reactive Oxygen Species (ROS) and the sensory neurovascular component
Rabea Graepel BSc, Jennifer Victoria Bodkin BSc, MRes, & Susan Diana Brain BSc, PhD

5) Mitochondrial Reactive Oxygen Species in Myocardial Pre- and Post-Conditioning
Ariel R. Cardoso, Bruno B. Queliconi* and Alicia J. Kowaltowski

6) Coenzyme Q9/Q10 and Healthy Heart
Samarjit Das, Somak Das and Dipak K. Das

7) Oxidative and proteolytic stress in homocysteine associated cardiovascular diseases
Karni S. Moshal, Munish Kumar, Neetu Tyagi, Paras Kumar Mishra, Saumi Kundu, Suresh C. Tyagi

8) Functional studies of NADPH oxidases in human vasculature
Tomasz J Guzik

9) Relationship of the CYBA gene polymorphisms with oxidative stress and cardiovascular risk
Guillermo Zalba, PhD and Javier Diez, MD, PhD

10) Redox-related genetic markers of cardiovascular diseases
Christian Delles, MD, and Anna F. Dominiczak, MD

11) NADPH oxidases and blood-brain barrier dysfunction in stroke
Timo Kahles, MD, Sabine Heumuller and Ralf P. Brandes, MD

12) Smoking-Induced Oxidative Stress in the Pathogenesis of Cardiovascular Diseases
David Bernhard PhD

13) Oxidative Stress in Vascular Aging
Anna Csiszar, MD, PhD and Zoltan Ungvari, MD, PhD

14) Oxidative Stress and Cardiovascular Disease in Diabetes Mellitus
Divya Gupta, Kathy K. Griendling and W. Robert Taylor

15) Reactive Oxygen Species, Oxidative Stress and Hypertension
Rhian M Touyz MD, PhD, Andreia Chignalia, MSc, Mona Sedeek PhD

16) Peripartum cardiomyopathy: Role of STAT-3 and reactive oxygen species
Denise Hilfiker-Kleiner, PhD, Arash Haghikia, MD, andAndres Hilfiker, PhD

17) Oxidative stress and inflammation after coronary angiography
Raymond Farah MD

18) Oxidative Stress in Cardiac Transplantation
Galen M. Pieper, Ph.D. and Ashwani K. Khanna, Ph.D

19) Oxidative Stress and Atrial Fibrillation
Ali A. Sovari and Samuel C. Dudley, Jr.

20) Oxidative stress and the anti-oxidative capacity in myocardial infarction
Yao Sun, MD, Ph.D.

21) Oxidative Stress and Redox Signalling in Cardiac Remodelling
Min Zhang MD, PhD, Alex Sirker MRCP and Ajay M Shah MD, FmedSci

22) Oxidative Stress and Cardiovascular Fibrosis
Subramanian Pennathur, Louise Hecker, and Victor J. Thannickal

23) Oxidative Risk Factors for Cardiovascular Disease in Women
M. Gago-Dominguez, Xuejuan Jiang, J. Esteban Castelao

24) Protective effects of food on cardiovascular diseases
Alfonso Giovane, Biol.D., Ph.D., and Claudio Napoli, M.D., Ph.D., MBEth.

25) Novel Synthetic Antioxidants and Nitrated Lipids: From Physiology to Therapeutic Implications
Gloria V. Lopez , PhD and Homero Rubbo, PhD

26) Thioredoxin in the cardiovascular system - towards a thioredoxin-based anti-oxidative therapy
Bradford C. Berk

27) The protective effect of melatonin on the heart
Amanda Lochner

28) Exercise Induced cardioprotection: Overview with an emphasis on the role of anti-oxidants
Karyn L. Hamilton and John C. Quindry

29) Antioxidative properties of statins in the heart
Oliver Adam MD, Ulrich Laufs MD