Main description:

During the last 30 years it has become clearly evident that oxidative stress and free radical biology play key roles in carcinogenesis, cancer progression, cancer therapy, and normal tissue damage that limits treatment efficacy during cancer therapy. These mechanistic observations have led to the realization that free radical biology and cancer biology are two integrally related fields of investigation that can greatly benefit from cross fertilization of theoretical constructs.

The current volume of scientific papers was assembled under the heading of Oxidative Stress in Cancer Biology and Therapy in order to stimulate the discussion of how the knowledge gained in the emerging field of oxidative stress in cancer biology can be utilized to more effectively design interventions to enhance therapeutic responses while causing fewer treatment limiting complications. The chapters contained in this volume provide highly informative emerging perspectives on how that selective enhancement of oxidative stress in cancerous tissues can be used as a target for enhancing therapeutic outcomes as well as how selective inhibition of oxidative stress could spare normal tissue damage and inhibit carcinogenesis. In this regard, the book represents an outstanding resource for both basic and translational scientists as well as clinicians interested in the field of oxidative stress and cancer therapy.

Contents:

Mitochondria-Mediated Oxidative Stress and Cancer Therapy.- The Role of Akt Pathway Signaling in Glucose Metabolism and Metabolic Oxidative Stress.- Enhancement of Cancer Therapy Using Ketogenic Diets.- Superoxide Dismutase and Cancer Therapy.- Radiosensitization and Chemosesitization of Multicellular Spheroids by 2-deoxy-D-glucose is Stimulated by a Combination of TNF and Glucodeprivation-Induced Oxidative Stress.- Chemotherapy-Induced Oxidative Stress in Non-Targeted Normal Tissues.- Tetrahydrobiopterin and Endothelial Nitric Oxide Synthase: Implications for Radiation-Induced Endothelial Dysfunction and Normal Tissue Radiation Injury.- Amifostine and the Endogenous Cellular Antioxidant Enzyme Manganese Superoxide Dismutase in Radioprotection.- Redox Regulation of Stem Cell Compartments: The Convergence of Radiation-Induced Normal Tissue Damage and Oxidative Stress.- Functional Imaging in the Assessment of Normal Tissue Injury Following Radiotherapy.- Histone Deacetylase Inhibitors, Oxidative Stress, and Multiple Myeloma Therapy.- Curcumin, Oxidative Stress, and Cancer Therapy.- Oxidative Stress and Pancreatic Cancer.- Oxidative Stress and Photodynamic Therapy for Prostate Cancer.- Oxidative Stress in Prostate Cancer.- Role of Vitamin E in Prostate Cancer.- Pentoxifylline, Vitamin E, and Modification of Radiation Induced Fibrosis.- Antioxidants, Anorexia/Cachexia, and Oxidative Stress in Patients with Advanced-Stage Cancer.- Radiation Protection by MnSOD-Plasmid Liposome Gene Therapy.- Antioxidants and Inhibition of Cisplatin-Induced Kidney Injury: Role of Mitochondria.- Carrier-Mediated and Targeted Cancer Drug Delivery.