Main description:

This volume systematically reviews the basic science and clinical knowledge of the role of free radicals and antioxidants, collectively known as "oxidative stress," in the pathology of Alzheimer's disease. It describes the most current diagnostic tools, laboratory methods and technology, and suggests ways of prevention and treatment to emphasize the concept of the bench-to-bedside approach. Studies on Alzheimer's Disease provides thorough coverage of emerging technology and medical applications including discussions of biomarkers and antioxidants as therapeutic agents, and several more relevant aspects. In addition, this book promotes the concept of using biomarkers representative of oxidative stress reactions and free-radical damageand describes the effects of antioxidants in treating disease in clinical trials. This content is invaluable to both researchers and clinicians studying the development of and treating patients with Alzheimer's Disease.

Contents:

Section 1: Hypotheses.- Oxidative stress: impact in neuroscience research.- Oxidative stress and Alzheimer's disease.- Inflammation and Oxidation: a link in Alzheimer' disease pathogenesis.- GAPDH: -amyloid mediated iron accumulation in Alzheimer's disease.- A in mitochondria: one piece in the Alzheimer's disease puzzle.- The role of the plasma membrane redox system in the pathognesis of Alzheimer's disease.- Section 2: Mechanisms.- Metal dysfunction in Alzheimer's disease.- Brain Oxidative Stress in the Pathogenesis and Progression of Alzheimer's Disease.- Cholesterol metabolism and oxidative stress in Alzheimer's disease.- Brain hypometabolism, oxidative stress, maternal transmission and risk of late-onset Alzheimer's disease.- Stress and HPA axis dysfunction in Alzheimer's disease.- Section 3: Clinics.- Diabetes mellitus and its impact on sporadic Alzheimer's disease.- Peripheral biomarkers of oxidative tress in Alzheimer's disease.- Nutrition lifestyle and oxidative stress: prevention in Alzheimer's disease.- Are antioxidants food and nutrients useful in preventing cognitive decline?.- Antioxidant clinical trials in Mild Cognitive Impairment and Alzheimer's disease.