Main description:

Studies on Retinal and Choroidal Disorders examines the role that oxidative and nitrosative stress plays in the complex physiology and pathophysiology of the retina and choroid. Both the basic science researcher and the clinical practitioner can use this book as a guide to the current understanding of retinal and choroidal cellular mechanisms involved in aging and disease. Beginning with a review of oxidative stress and inflammation in the pathoetiology of AMD and a review of the complement system in the retina, the book then takes a detailed look at oxidative stress in lipid metabolism and oxidized lipoproteins in the retina. It examines the anti-apoptotic activity of -crystallins in the presence of glutathione, oxidative stress in the mitochondria and endoplasmic reticulum, the role of iron in retinal disease, the mechanisms of pathological VEGF expression, NAPDH oxidase mechanisms, and Hepatocyte Growth Factor in oxidative stress in the retina.

A detailed look at the Ccl2-/-/Cx3cr1-/- mouse model of AMD follows. Then a detailed examination of the systemic changes in AMD is followed by a discussion of cerium oxide nanoparticle reduction of oxidative stress. Two chapters discuss progenitor cells in the cause and treatment of retinal diseases including AMD and diabetic retinopathy. Natural compounds in the prevention and treatment of retinal diseases are exhaustively presented, followed by a chapter on serotonin 5-HT1A receptor agonists in oxidative stress of the retina. The current anti-VEGF treatment strategies of neovascular AMD are then given. The volume continues with a detailed look at nitric oxide and inducible nitric oxide synthase in retinal vascular disease, an explanation of an in vivo technique of studying the effect of lipid hydroperoxides on circulating leucocytes in the retina, an excellent review of oxidative stress in retinopathy of prematurity, and a look at VEGF induced oxidative stress in the retinal ganglion cell. The book ends with a detail examination of the role of carotenoids in retinal health and disease. These 31 chapters summarize what is known about oxidative stress in retinal and choroidal disorders. All those involved with degenerative diseases of the eye will find Studies on Retinal and Choroidal Disorders to be illuminating and comprehensive.

Contents:

Review of Emerging Treatments for Age-Related Macular Degeneration.- Complement Pathways and Oxidative Stress in Models of Age-Related Macular Degeneration.- Oxidative Modifications As Triggers of AMD Pathology.- Role of Malondialdehyde in the Age-Related Macular Degeneration.- Bisretinoid Lipofuscin in the Retinal Pigment Epithelium: Oxidative Processes and Disease Implications.- Age-related Changes in RPE Lipofuscin Leads to Hydrophobic Polymers.- Docosahexaenoic Acid Signalolipidomics in the Homeostatic Modulation of Photoreceptor/Retinal Pigment Epithelial Cell Integrity During Oxidative Stress.- Role of Photoreceptor Retinol Dehydrogenases in Detoxification of Lipid Oxidation Products.- Glutathione Metabolism and its Contribution to Anti-Apoptotic Properties of -Crystallins in the Retina.- The Role of Mitochondrial Oxidative Stress in Retinal Dysfunction.- Endoplasmic Reticulum Response to Oxidative Stress in RPE.- The Role of Iron in Retinal Diseases.- Mechanisms of Pathological VEGF Production in the Retina and Modification with VEGF-Antagonists.- NADPH Oxidase in Choroidal Neovascularization.- Deposition and Oxidation of Lipoproteins in Bruch's Membrane and Choriocapillaris are "Age-Related" Risk Factors with Implications in Age-Related Macular Degeneration.- Hepatocyte Growth Factor Protection of Retinal Pigment Epithelial Cells.- The Role of Oxidative Stress in the Retinal Lesion of Ccl2/Cx3cr1 Deficiency Mouse.- Oxidative Stress and Systemic Changes in Age-Related Macular Degeneration.- Cerium Oxide Nanoparticle Reduction of Oxidative Damage in Retina.- Transformation of Progenitor Cells for Treatment of Retinal Disease.- Natural Compounds in Retinal Diseases.- Serotonin 5-HT1A Receptor Agonists in Oxidative Stress and Retinal Disease.- Anti-VEGF Monotherapy Treatment Strategies for Neovascular AMD.- Combination Treatment Strategies in Neovascular AMD.- Dysfunction of Circulating Endothelial Progenitor Cells in Diabetic Retinopathy.- Nitric Oxide Synthase in Retinal Vascular Diseases.- Lipid Hydroperoxide Induced Leukocyte-Endothelium Interaction in the Retinal Microcirculation.- The Role of Reactive Oxygen Species and Oxidative Signaling in Retinopathy of Prematurity.- VEGF Inhibitor Induced Oxidative Stress in Retinal Ganglion Cells.- The Role of the Macular Carotenoids as a Blue Light Filter and an Antioxidant.- Macular Pigment Carotenoids and Their Roles in Human Eye Health and Diseases.