Main description:

This next volume in our established series proposes to systematically review the basic science and clinical knowledge of the role of free radicals and antioxidants, collectively known as "oxidative stress", in the pathology of arthritis and other joint diseases. It will describe the most current diagnostic tools , laboratory methods and technology, to suggest ways of prevention and treatment and to emphasize the concept of the bench-to-bedside approach. The book will also provide specific coverage on emerging technology and medical applications including discussions of biomarkers and antioxidants as therapeutic agents and several more relevant aspects. In addition, the book will promote the concept of using biomarkers representative of oxidative stress reactions and free radical damage , as well as describe the effect of antioxidants in treating disease in clinical trials. The content will be valuable to researchers studying the development of arthritis/joint disease, and clinicians treating patients with these diagnoses.

Contents:

Biomarkers of oxidative stress in joint diseases.- Regulation of T-cell functions by oxidative stress.- Nitric oxide and the respiratory chain in synovial cells and chondrocytes.- Adipokines, molecular players at the crossroad between inflammation and oxidative stress. Role in arthropathies.- Regulation of cartilage and bone metabolism by oxidative stress.- Role of oxidative stress in bone aging.- Genetic Component of Oxidative Stress in Rheumatoid Arthritis.- Oxidative stress in rheumatoid arthritis.- Oxidative stress and premature atherosclerosis in RA.- Role of Oxidative Stress and Reactive Oxygen Radicals in the Pathogenesis of Systemic Sclerosis.- Antioxidant and anti-inflammatory properties of heme oxygenase-1 in osteoarthritic articular cells.- Oxidative stress at the crossroads between osteoarthritis and metabolic syndrome.- Metabolic syndrome and gout.- Natural Antioxidants in the pharmacological treatment of rheumatic immune and inflammatory diseases.- Antioxidants in the treatment of osteoarthritis and bone mineral loss.- Anti-cytokine agents to combat oxidative stress.- Oxidative Conditioning and treatment for Osteoarthritis.- The role of sirtuins in arthritis.- MicroRNA molecules, master regulators, biomarkers and potential therapies.- Estrogen-dependent transcriptional activity, a protection against ROS in osteoarthritis.