In spite of the protection of the CNS there are situations where immune responses occur due to different disease processes. While antigen-specific cells of the adaptive immune response are not normally functional in the CNS tissue, CNS resident cells respond to infection or insult. One mechanisms is through the induction of apoptosis in virus infected neurons, which may be protective or pathogenic depending on the extent of cell death.
It is well known that the CNS is normally protected from immune effectors because of the potential of irreversible damage to the nervous tissue. Nevertheless, there are situations where immune responses occur in the CNS due to different disease processes. Some of these responses are purely pathogenic while others clear or contain disease causing pathogens. In this volume, the mechanisms responsible for the varied outcomes are compared and contrasted.
Hierarchy of immune responses to antigen in the normal brain.-Cytokines and chemokines in the CNS.-Cytokines in the degenerative brain diseases: Lessons from transgenic animals.-Innate immune responses in viral encephalitis.-Apoptosis in viral infections of neurons: a protective or pathologic host response.-Markers of central nervous system glia and neurons in vivo during normal and pathological conditions.-The role of T cells in brain pathology.-Immunopathology and immunoprotection in CNS virus infections: mechanisms of virus clearance from the CNS.-HIV-1 and the central nervous system.-HTLV-1 mediated immunopathological CNS disease.-Listeria monocytogenes: a model to study invasion and spread of in the central nervous system.-Parasites and the brain: Neuroinvasion, immunopathogenesis and neural dysfunctions.-Immune response to glioblastoma: an avenue of effective cancer therapy or a mere epiphenomenon?.-Subject index