Main description:

The role of free radicals and oxidative stress in neurological disorders has only recently been recognized, leaving clinical neurologists to seek in vain for information on the subject even in major textbooks. What published information there is may consist of brief reminders of the possible association of superoxidase dismutase with familial amyotrophic lateral sclerosis and nitrous oxide with migraine. With luck they may also find information on the purported role of free radicals in the pathogenesis of traumatic brain injury. Oxidative Stress and Free Radical Damage in Neurology sets the record straight, focusing on clinical and research issues regarding the interplay of free radicals and the human nervous system. Crucially, the chapters cover numerous antioxidants and their possible therapeutic role in neurological disorders.

Key illnesses such as epilepsy, multiple sclerosis and Parkinson's are analyzed, and chapters also examine more general issues such as the link between free radicals and inflammation of the central nervous system. Clinicians and laboratory researchers alike will find that this book augments their understanding not only of the widespread involvement of free radicals in the central nervous system but also of some uncertainties surrounding whether free radical damage in neurology plays a primary or secondary role.

Contents:

Preface : Gadoth N and Goeble H.H.

1. The role of free radicals in the nervous system. Freidman J.

2. Why is the nervous tissue vulnerable to oxidative stress? Freidman J.

3. Free radicals in perinatal hypoxic-ischemic encephalopathy: A fine balance . Perlman M and Cheung P-Y.

4. Oxidative Stress in Neonatal Hypoxic-Ischemic Encephalopathy
Todd KG, Jantzie LL and Cheung P-Y.

5. Oxidative stress in multiple sclerosis pathology and therapeutic potential of Nrf2 activation . de Vries HE, Schreibelt G and van Horssen J.

6. Free Radicals in Central Nervous System Inflammation, Hooper CD , Fabis MJ and Roy A .

7. The Role of Reactive Oxygen Species in the Pathogenesis of Traumatic Brain Injury, Shohami E and Kohen R .

8. Distinct roles of cyclooxygenases-1 and -2 in inflammatory and excitotoxic
brain injury , Aid S, Choi SH, Toscano CD and Bosetti F.

9 . Stroke and Oxidative Stress. Vignini A .

10. Free Radicals in Epilepsy . Simn-Tov T and Gadoth N.

11. Neurological disorders associated with iron misdistribution:
The therapeutic potential of siderophores. Kakhlon O, Breuer W, Munnich A and Cabantchik IZ.

12. Oxidative stress in Parkinson's disease . Vaya J, Aluf Y and Finberg JPM .

13. "Tetrahydrobiopterin Deficiency". Koenig MK and Butler IJ .

14. Radicals Attack the Ear .The Toll: A Loss of Hearing. Sohmer H and Adelman C.

15. Mitochondrial Encephalomyopathies. Park SY and. Haller RG.

16. Potential role of oxidative damage in neurological manifestations of acute intermittent porphyria. Pischik E and Kauppinen R.