(To see other currencies, click on price)
MORE ABOUT THIS BOOK
Main description:
Some important constraints of anesthesia must be taken into consideration when the pharmacological properties of modern anesthetics are discussed. The most imp- tant of these could be that the target effect be achieved preferably within seconds, at most within a few minutes. Similarly, offset of drug action should be achieved within minutes rather hours. The target effects, such as unconsciousness, are pot- tially life-threatening, as are the side effects of modern anesthetics, such as respi- tory and cardiovascular depression. Finally, the patient's purposeful responses are not available to guide drug dosage, because, either the patient is unconscious, or more problematically, the patient is aware but unable to communicate pain because of neuromuscular blockade. These constraints were already recognised 35 years ago, when in 1972 Volume XXX entitled "Modern Inhalation Anesthetics" appeared in this Handbook Series. The present volume is meant as a follow up and extension of that volume. At the beginning of the 1970's anesthesia was commonly delivered by inhalation, with only very few exceptions. The clinical understanding of that time considered anesthesia as a unique state achieved by any of the inhalation anesthetics, in- pendent of their specific molecular structure. "The very mechanism of anesthetic action at the biophase" was discussed within the theoretical framework of the "u- tary theory of narcosis".
Contents:
Molecular Mechanisms of Anesthetic Action.- The Site of Anesthetic Action.- Inhibitory Ligand-Gated Ion Channels as Substrates for General Anesthetic Actions.- Actions of Anesthetics on Excitatory Transmitter-Gated Channels.- Voltage-Gated Ion Channels.- G-Protein-Coupled Receptors.- Modern Inhalation Anesthetics.- Inhalation Anaesthesia: From Diethyl Ether to Xenon.- General Anesthetics and Long-Term Neurotoxicity.- Special Aspects of Pharmacokinetics of Inhalation Anesthesia.- Inhalational Anaesthetics and Cardioprotection.- Non-Immobilizing Inhalational Anesthetic-Like Compounds.- Modern Intravenous Anesthetics.- Propofol.- Pharmacokinetics and Pharmacodynamics of GPI 15715 or Fospropofol (Aquavan Injection) - A Water-Soluble Propofol Prodrug.- Etomidate and Other Non-Barbiturates.- Remifentanil and Other Opioids.- Ketamine.- Midazolam and Other Benzodiazepines.- Pharmacokinetics-Pharmacodynamics Based Administration of Anesthetics.- The Effect of Altered Physiological States on Intravenous Anesthetics.- Anesthetics Drug Pharmacodynamics.- Defining Depth of Anesthesia.- Target Controlled Anaesthetic Drug Dosing.- Advanced Technologies and Devices for Inhalational Anesthetic Drug Dosing.- Hypnotic and Opioid Anesthetic Drug Interactions on the CNS, Focus on Response Surface Modeling.
PRODUCT DETAILS
Publisher: Springer (Springer-Verlag Berlin and Heidelberg GmbH & Co. K)
Publication date: November, 2010
Pages: 516
Weight: 783g
Availability: Available
Subcategories: Accident & Emergency Medicine, Anaesthetics and Pain, Pharmacology
From the same series
Roger G. Pertwee
Philip K. Moore
Kathleen M. Kantak
Alan Cowan
Hans-Georg Schaible
Arnold von Eckardstein
Mark A. Geyer
Botond Berde
Lorenzo A. Pinna
Arnold von Eckardstein
Mark A. Geyer
Anthony R.M. Coates
Vera Regitz-Zagrosek
Ursula F. Habenicht
Christoph Stein
Fabrizio Benedetti
Paolo Gresele
O. Eichler
Clive P. Page
Peter Ruben
G. Peters
Gary R. Lewin
Allison D. Fryer
Hans-Georg Joost
Vsevolod V. Gurevich
Hannsjorg W. Seyberth
Sharron H. Francis
George B. Koelle
Marc Humbert
G Kimmerle
Martha Merrow
Erich Gulbins
Martin C. Michel
Mathias Schwanstecher
Erich Gulbins
Martin F. Fromm
Ross G. Cameron
Hanns Mohler
Mark A. Geyer
F. Clementi
Peter Holzer
Gaetano Di Chiara
Anthony R. M. Coates
David S. Latchman
Siamon Gordon
Bernard Testa
Michael Oettel
B. Mayer
Klaus, von der Helm
Sheldon H. Preskorn
Lutz Hein
Heinz Nau
Stanley T. Crooke
J.M. Monti
Martin C. Michel
Vera Regitz-Zagrosek
Mark A. Geyer
G. Peters
Paolo Gresele
Manfred Gossen
Maynard B. Chenoweth
W. McD. Armstrong
Clive P. Page
Monika Schafer-Korting
Detlef Thieme
Fiona Cunningham
Vittorio Erspamer
Hans H. Ussing
Oskar Eichler
Ervin G. Erdös
S. Bettini
R.E.M. Bowden
John Morley
P.S. Randall
H. Winkler
R Jahn
J. Harenberg
F. Bachmann
D.J. Atherton
M.T. Jones
Frank A. Smith
Timothy D. Warner
Jochen Kuhlmann
James R. Gillette
Joel Bockaert
M. Chatterjee
A.P. Weetman
M. Sovak
Clive P. Page
James William Fisher
Hans-Georg Joost
D.I. Abramson
H.P. Witschi
R. Assan
Alfred J. Clark
J.M. van Rossum
Helmut Greim
Allison D. Fryer
Michael Oettel
M.L. Sears
R. Hess
P.E. Came
C.F. Arlett
H. Mehnert
W.N. Kelley
Luc P. Balant
Alan C. Sartorelli
Gregory R. Mundy
W. R. Martin
Peter Perlman
Michael B. Sporn
Harold C. Hodge
David R. Brown
C. Muller
J. Erik Jorpes
H.E. Voss
Peter Frederick Baker
Pedro Cuatrecasas
Laszlo Szekeres
Fritz Markwardt
R. Baserga
D.A. Kharkevich
H. Vanden Bossche
Stephen H. Caldwell
Ronald T. Borchardt
Alain L. de Weck
Lawrence E. Bryan
T.J. Campbell
F. Lang
K. Bartmann
Donald B. Calne
E.M. Johnson
G.H. Hitchings
Arnold L. Demain
Eugen Dorzbach
U. Peters
M. Green
A. S. Milton
R. Baurain
Brian W. Fox
W. Bleifeld
P. Actor
H. Vanden Bossche
Victor P. Whittaker
Ullrich Trendelenburg
D. Janz
Börje Uvnäs
H.G. Baumgarten
J. A. Nathanson
Frederick C. Kauffman
S. Silver
Kurt Greeff
B. Babudieri
J.G. Banwell
T.T. Aoki
A.L. Jr. Ager
M. Ackenheil
M. Rocha e Silva
Carlo Patrono
Hamao Umezawa
W. Rogalski
G. R. Strichartz
E.C. Foulkes
P. Needleman
E. Anggard
H. Schmidt
C. Braestrup
L.G. Abood
D.A. Kharkevich
C.-Y. Lee
Charles D. Kochakian
Robert Charlier
A.C. Allison
I.H. Page
James R. Gillette
Hermann Blaschko
K.W. Bock
Dean H. Lockwood
A. Dickenson
Franz von Bruchhausen
P.F. D'Arcy
Robert J. Kavlock
Andrew C.G. Uprichard
P.J. Lefebvre
Mervyn J. Eadie
Franz Hefti
Ross G. Cameron
John G. Csernansky
Michael J. Kuhar
Hannsjorg W. Seyberth
Sharron H. Francis
Mathias Schwanstecher
Martin C. Michel
Martin R. Wilkins
Martin F. Fromm
Peter Redfern
Klaus Aktories
Jurgen Behrens
Harri U. Vainio
Michael Williams
Dennis W. Choi
Gaetano Di Chiara
Peter Jonas
Salvador Moncada
Stefan Bauer
Markus Schwaiger
Markus Schwaiger
Hans-Georg Krausslich
Veit M. Flockerzi
Harald H.H.W. Schmidt
Thomas C. Sudhof
Eric Beitz
Kian Fan Chung
Andreas Michael Zeiher
Yuti Chernajovsky
Jack E. Henningfield
Giovanna Lombardi
Salvador Moncada
Florian Holsboer
Enno Klussmann
Clive P. Page
Bertil B. Fredholm
Ursula F. Habenicht
Fiona Cunningham
Monika Schafer-Korting
Matthias Gaestel
Volker A. Erdmann
Robert E. Kass
Harald Sitte
Detlef Thieme
Domenico Spina
Constance N. Wilson
Jack E. Henningfield
Eric Beitz
Harald H.H.W. Schmidt
Giovanna Lombardi
Hans-Georg Krausslich
Kian Fan Chung
Markus Schwaiger
Markus Schwaiger
Enno Klussmann
Anna M. Wobus
Jurgen Schuttler
Thomas C. Sudhof
Stefan Bauer
Yuti Chernajovsky
Andreas Michael Zeiher
Veit M. Flockerzi
Christoph Stein
Salvador Moncada
Salvador Moncada
Harald Sitte