Xenotransplantation could have an impact on at least three aspects of medicine. The first is as a means of overcoming a severe shortage of human donor organs for the treatment of organ failure. The second aspect relates to the possibility that a xenogeneic organ would not be susceptible to infection by a "human" virus and thus the xenograft might resist injury caused by such viruses. The third and, as of yet, unexplored aspect relates to a means of delivering genes for therapeutic purposes thus overcoming some of the limitations of "conventional" gene therapy.
Genetic modification of xenografts.-Public health risks - patient versus society in an emerging field.-Cross-species infections.-Non-human primate herpesviruses: importance for xenotransplantation.-Understanding xenotransplantation risks from non-swine hepatitis E virus: cross-species infection and risk in xenotransplantation.-Molecular cloning and functions characterization of infectious PERV and development of diagnostic tests.-Xenotransplantation - Federal regulatory considerations.-Subject index