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Transcriptional Corepressors: Mediators of Eukaryotic Gene Repression
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Main description:

Corepressors are newly discovered assemblies of proteins that play essential roles in eukaryotic gene regulation. Recent discoveries about corepressors have provided new insights into the molecular basis of gene regulation, and have established surprising connections between the mechanisms of action of a wide variety of transcriptional regulators. The reviews in this volume critically discuss the nature, mechanisms of action, and physiological roles of corepressors in a diverse assortment of biological systems. Both basic and clinical investigators will be able to find relevant information. The comprehensive nature of the compilation, and the breadth of the reviews, are intended to provide the reader with an excellent introduction to the newly emergent and rapidly-growing field of corepressor research. A valuable and detailed reference guide.


Contents:

Molecular Mechanisms of Corepressor Function.- Role of Histone Deacetylase Complexes in the Regulation of Chromatin Metabolism.- Corepressor Proteins and Control of Transcription in Yeast.- Corepressor Proteins in Drosophila Development.- Corepressors and Nuclear Hormone Receptor Function.- Regulation of SMRT and N-CoR Corepressor Function.- Corepressors and Retinoblastoma Protein Function.- Smad Transcriptional Corepressors in TGFß Family Signaling.- Role of Nuclear Receptor Corepressors in Leukemogenesis.


PRODUCT DETAILS

ISBN-13: 9783642087097
Publisher: Springer (Springer Berlin Heidelberg)
Publication date: December, 2010
Pages: 208
Weight: 332g
Availability: POD
Subcategories: General Issues, Immunology, Microbiology
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