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MORE ABOUT THIS BOOK
Main description:
In the last few years the major effect that RNAi has had in invertebrate systems is beginning to take hold in mammalian systems through both single gene knockdown experiments and genome-scale screens. In the next decade, there will no doubt be both notable successes and failures as we attempt to apply this genetic tool to various biological problems. Through the introduction of RNAi, mammalian systems have finally gained admittance to the pantheon of model genetic systems.
Contents:
RNA interference in mammalian cell systems.- RNAi pathway in C. elegans: The Argonautes and collaborators.- Genetics and biochemistry of RNAi in Drosophila.- Role of Dicer in post-transcriptional RNA silencing.- The mechanism of RNase III action: How Dicer Dices.- microRNA metabolism in plants.- Structure-function relationships among RNA-dependent RNA polymerases.- RNAi-mediated chromatin silencing in fission yeast.- A role for RNAi in heterochromatin formation in Drosophila.- RNA mediated transcriptional gene silencing in human cells.- RNA silencing in mammalian oocytes and early embryos.- Identifying human MicroRNAs.- Subject index.
PRODUCT DETAILS
Publisher: Springer (Springer-Verlag Berlin and Heidelberg GmbH & Co. K)
Publication date: September, 2014
Pages: 288
Weight: 444g
Availability: Available
Subcategories: Genetics, Immunology, Microbiology
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