Main description:

Pediatric Neoplasia: Advances in Molecular Pathology and Translational Medicine presents many of the major, relevant advances in molecular pathology that are occurring in the field of pediatric oncology and will serve as a useful overview for resident and attending physicians as well as scientists interested in understanding the molecular pathology of pediatric cancer in the context of clinical medicine. Chapters are based upon organ systems, and each is written by an expert or pair of experts in their field with subspecialty training and extensive clinical experience. Each chapter describes a variable number of tumors and includes an overview of the classification system and clinicopathological characteristics of each tumor. This is followed by a discussion of the molecular pathology relevant to a specific tumor, including specific molecular markers of the tumors, methods used for diagnosis or clinical management, clinical significance of the markers, and if appropriate, a description or discussion of current activities in translational research or issues that need to be addressed in the future. Pediatric Neoplasia: Advances in Molecular Pathology and Translational Medicine will be of great value to pathologists, oncologists, hematologists, internal medicine and pediatric specialists, as well as pharmaceutical professionals and translational and clinical researchers.

Contents:

1. Towards Personalized Medicine in Pediatric Cancer: Genome-Wide Strategies to Investigate Cancer Risk and Response to Therapy.- 2. Acute Leukemia.- 3. Molecular Techniques Used in Evaluation of Pediatric Acute Leukemia.- 4. Myelodysplasia and Myeloid Proliferations.- 5. Childhood Lymphoma.- 6. Children are Not Small Adults: Importance of Molecular Analysis for Diagnosis, Prognosis, and Treatment of Pediatric CNS Tumors.- 7. Pediatric Bone Tumors.- 8. Soft Tissue "Small Round Blue Cell Tumors" of Childhood.- 9. Fibroblastic and Myofibroblastic Pediatric Soft Tissue Tumors.- 10. Molecular Analysis in Pediatric Renal Tumors.- 11. Hepatoblastoma: New Insights into the Biology of Embryonal Tumors of the Liver.