Main description:

Molecular and Translational Vascular Medicine will serve as a state-of-the-art resource for physicians and translational medical researchers alike who are interested in the rapidly evolving field of vascular medicine. The text provides new insight into the basic mechanisms of classic vascular pathophysiologic processes like angiogenesis, atherosclerosis, thrombosis, and vasculitis. Furthermore, it covers new areas of investigation including the role of the ubiquitin proteasome system in vascular disease, endothelial progenitor cells for disease treatment, and the genetic basis of thoracic aortic aneurysms. Lastly, this volume includes sections on the newly emerging field of therapeutic angiogenesis, and the developing technology of nanoparticle-based imaging and therapeutic treatment of the diseased vasculature. All chapters are written by established experts in their fields, including pathologists, cardiovascular surgeons, and internists as well as translational biomedical researchers in a wide range of disciplines. While comprehensive, the material is presented in a manner that simplifies the complex pathophysiologic mechanisms that underlie common vascular diseases.

Molecular and Translational Vascular Medicine will be of great value to a broad audience including internists, cardiovascular and vascular surgeons, pathologists, residents and fellows, as well as translational biomedical researchers.

Contents:

Section 1: Recent advances in understanding and imaging the molecular and genetic basis of vascular diseases.

Ch. 1- The Molecular Biology and Genetics of Aneurysms
Helena Kuivaniemi
Gerard C. Tromp
David J. Carey
James R. Elmore

Ch. 2- The Molecular Biology and Treatment of Systemic Vasculitis in Children
Despina Eleftheriou
Paul A. Brogan

Ch. 3- Recent Insights into the Molecular and Cellular Contributions to Venous Thrombosis
Peter K. Henke
Jose Antonio Diaz
Daniel D. Myers, Jr.
Thomas W. Wakefield

Ch. 4- The Ubiquitin Proteasome System in Endothelial Cell Dysfunction and Vascular Disease
Najeeb A. Shirwany
Ming-Hui Zou

Ch. 5- Molecular Imaging of Vascular Inflammation, Atherosclerosis, and Thrombosis
Dan Jane-wit
Mehran M. Sadeghi

Section 2: The therapeutic potential of angiogenesis, nanomedicine, and endothelial progenitor cells in the treatment of vascular disease

Ch. 6- Molecular Regulation of Vasculogenesis and Angiogenesis: Recent Advances and Future Directions
George E. Davis

Ch. 7- Therapeutic Angiogenesis for Critical Limb Ischemia: Complex Mechanisms and Future Challenges
Yihai Cao

Ch. 8- Modulating the proliferative response to treat restenosis after vascular injury
Vicente Andres Garcia
Jose Javier Fuster
Carlos Silvestre Roig
Rainer Wessely

Ch. 9- Cardiovascular Nanomedicine: Challenges and Opportunities
Biana Godin
Ye Hu
Saverio La Francesca
Mauro Ferrari

Ch. 10- Endothelial Progenitor Cells in the Treatment of Vascular Disease
Gareth J. Padfield