Main description:

This volume explores the mechanisms of resistance to targeted therapeutics. The focus is on the cancer cell signaling network, although other mechanisms of resistance including target mutation, and new areas of study such as cancer stem cells are included.

Targeted Therapies: Mechanisms of Resistance highlights examples of changes in the signaling network in response to inhibition of a signaling event and underscores the importance in having a mechanistic understanding of the signaling network in cancer for developing effective targeted cancer therapies. Moreover, cutting edge tools to analyze the cell signaling network will be discussed. This includes the leading edge of techniques as well as computational biology and systems theory. This volume provides the reader with both an overview as well as a detailed perspective on the mechanisms of resistance to targeted therapeutics and will be of great value to the oncologist, the physician-scientist treating patients and the translational scientist working on any aspect of targeted therapeutics.

Contents:

Foreword

Preface

Chapter 1

Resistance to Targeted Therapies As a Result of Mutation(s) in the Target

Alexis B. Cortot and Pasi A. Janne

Chapter 2

The Dynamics of the Cell Signaling Network; Implications for Targeted Therapies

Daniel G. Gioeli

Chapter 3

Cancer Signaling Network Analysis by Quantitative Mass Spectrometry

Jason R. Neil and Forest M. White

Chapter 4

Development and Implementation of Array Technologies for Proteomics: Clinical Implications and Applications

Julia D. Wulfkuhle, Menawar Khalil, Joseph C. Watson, Lance A. Liotta, and Emanuel F. Petricoin III

Chapter 5

Using Phosphoflow to Study Signaling Events of Sub Populations Resistant to Current Therapies

Omar D. Perez

Chapter 6

Mathematical and Computational Models in Cancer

Sudhir Chowbina, Kevin Janes, Shayn M. Peirce, and Jason Papin

Chapter 7

Somatic Evolution of Acquired Drug Resistance in Cancer

John W. Pepper

Chapter 8

Interrogating Resistance to Targeted Therapy Using Genetically Engineered Mouse Models of Cancer

Edward Gunther

Chapter 9

MicroRNA: A Potential Therapy Able to Target Multiple Cancer Pathways

Benjamin Kefas and Benjamin W. Purow

Chapter 10

Rational Combination of Targeted Agents to Overcome Cancer Cell Resistance

Yun Dai and Steven Grant