Nearly 25 years of intensive research have uncovered many diverse functions for the dimeric transcription factor known as NF-kappaB (nuclear factor-kappaB). NF-kappaB affects most aspects of cellular physiology—from immunity and inflammation to apoptosis, cell survival, growth, and proliferation
NF-kappaB transcription factors regulate a number of important physiological processes, including inflammation and immune responses, cell growth and survival, and the expression of certain viral genes
Moreover, NF-kappaB activity is elevated in and contributes to the pathology of several human diseases, including many cancers and chronic inflammatory diseases
This volume is focused on a transcription factor that started its life as a B cell-specific nuclear protein, but has matured to become one of the most extensively studied transcriptional regulators, found to control many pathophysiological processes: NF-kB. Articles in the volume, all of them written by the leading experts in the field, range from description of the NF-kB system and its basic components, its logic and its transcriptional regulatory functions to its participation in diverse processes, including inflammation, immunity, mucosal homeostasis and cancer. In addition to discussing the molecular biology and physiology of the NF-kB system, this volume also addresses the therapeutic targeting of NF-kB and its regulators. Thus, this volume is an important reading to both basic and translational scientists interested in different aspects of this highly versatile regulatory system.
Preface.- Understanding the Logic of IκB:NF-κB Regulation in Structural Terms.- NF-κB/Rel proteins and the humoral immune responses of Drosophila melanogaster.- Specialized chromatin patterns in the control of inflammatory gene expression.- IKK regulation and human genetics.- Control of NF-κB activity by proteolysis.- NF-κB and Innate Immunity.- NF-κB and mucosal homeostasis.- IKK and NF-κB mediated functions in carcinogenesis.- Macrophages and NF-κB in Cancer.- NF-kappaB in liver cancer – the plot thickens.- NF-kappaB as a target for oncogenic viruses.- Inhibition of NF-κB signaling as a strategy in disease therapy.- Subject index