Oral immunization has a fascinating and frequently successful history, yet it has been largely overshadowed by other immunization methods. Various vaccines that lead to the induction of antibodies in respiratory, gastrointestinal, and genitourinary tracts are currently under development, and others are in use for the immunization of animals as well as humans. This volume gives oral immunization the attention it deserves in light of recent methodological and technical advances in antigen delivery systems.
Oral Immunization and Mucosal Immune System.- Oral Immunization: Past and Present. With 2 Figures.- Overview of the Mucosal Immune System. With 4 Figures.- Antigen Delivery Systems.- Cholera Toxin and its Subunits as Potential Oral Adjuvants.- Selective Delivery of Antigens by Recombinant Bacteria.- Liposomes as Oral Adjuvants. With 1 Figure.- Biodegradable Micropheres: Vaccine Delivery System for Oral Immunization.- Viral Vaccines.- to Oral Immunization Against Viral Infections.- Oral Immunization and Secretory Immunity to Viruses.- Oral Immunization with Influenza Virus: Experimental and Clinical Studies.- Immune Responses to Influenza Virus in Orally and Systemically Immune Mice.- Efficacy of Inactived Influenza Vaccine Delivered by Oral Administration.- The Systemic and Mucosal Immune Response of Humans to Influenza A Virus.- Oral Immunization with Sendai Virus in Mice.- Immunity to Rotaviruses. With 1 Figure.- Rabies Oral Immunization.- Bacterial Vaccines.- Induction of the Mucosal Immune Response.- Systemic Immunization for the Induction of IgA Responses.- Prevention of Invasive Bacterial Diseases by Immunization with Polysaccharide-Protein Conjugates.- Protection Induced Against Acute Bronchitis — The Use of Human and Rat Models to Determine Mechanisms of Action of Oral Immunization with Haemophilus influenzae.- Oral Immunization for the Prevention of Dental Diseases.- Oral Immunization Against Cholera.- Oral Shigella Vaccines.- The Enteric Immune Response to Shigella Antigens.- Immune Response to Oral Salmonella Vaccines.- Oral Immunization: A Summary.