(To see other currencies, click on price)
MORE ABOUT THIS BOOK
Main description:
This volume represents the proceedings of a NATO Advanced Study Institute on "Molecular Aspects of Monooxygenases and Bioactivation of Toxic Compounds" which was held in ~e me (Izmir) Turkey, August 27 to September 7, 1989. The Institute emphasized the potential dangers of drugs, pollutants, pesticides, carcinogens, and both nutrient and non-nutrient food additives and their interactions at the molecular level. These xenobiotics are metabolized in phase I reactions by monooxygenases, primarly cytochrome P450-isozyme dependent, followed by phase II conjugation enzymes. The versatility of these enzymes is unique in biochemistry since they catalyze the metabolism of an almost limitless number of compounds through a diverse array of reactions. Although these metabolic sequences are usually detoxication mechanisms, in some cases the reactive intermediates are more mutagenic, more carcinogenic and ultimately more toxic than the parent compound. The Institute was devoted to recent scientific progress in the understanding of the biochemical and molecular properties of these enzymes and factors that influence the metabolism of chemicals to toxic and non-toxic compounds.
Overview lectures focused on xenobiotic metabolism by cytochrome P450, the flavin-containing monooxygenase, cytochrome b5, epoxide hydrolase, glutathione S-transferase and UDP-glucuronosyl transferase. Several additional presentations stressed various aspects of cytochrome P450 mediated metabolism including: specific forms in the rabbit and insects; topology in membranes; posttranslational modification; control of constitutive forms in the rat; hormonal and xenobiotic regulation; prostanoid metabolism; endogenous substrate metabolism; interaction with estrogenic pesticides; pesticide bioactivation. The Institute also included talks on interactions between enzymes and on benzene metabolism and toxicity.
Contents:
Cytochrome P450-Dependent Monooxygenase: An Overview.- The Flavin-Containing Monooxygenase (EC 1.14.13.8).- Multiple Forms of Rabbit Cytochrome P450: Comparison of Chemical, Physical, Immunological and Biocatalytic Properties.- Primary Structures and Regulation of Cytochrome P450 Isozymes 2 (IIB) and 5 (IVB) and the Flavin-Containing Monooxygenase in Rabbit Liver and Lung.- Insect Cytochrome P450.- I. Membrane Topology of Cytochromes P450: Elements and Measurement by Spectroscopic Techniques.- II. Membrane Topology of Cytochromes P450: Oligomers and Cooperativity.- NADPH-Dependent Cytochrome P450 Reductase A. Y. H. Lu.- Essential Features of NADH Dependent Cytochrome b5 Reductase and Cytochrome b5 of Liver and Lung Microsomes.- Electron Transfer from Cytochrome b5 to Cytochrome P450.- Functional Aspects of Protein-Protein Interactions of Cytochrome P450, Cytochrome b5 and Cytochrome P450 Reductase.- Posttranslational Modification by Phosphorylation: Control of Cytochrome P450 and Associated Enzymes.- Physiological and Pathophysiological Alterations in Rat Hepatic Cytochrome P450.- Ontogenesis of Liver Cytochromes P450.- Mechanism of Steroid Hormome Action A. Berkenstam.- Xenobiotic Regulation of Cytochrome P450 Gene Expression.- Prostanoid Metabolism and Biologically Active Product Formation.- Role of Cytochrome P450 in the Anabolism and Catabolism of Endobiotics.- Interactions of Estrogenic Pesticides with Cytochrome P450.- Effects of Inhibitors on the P450-Dependent Metabolism of Endogenous Compounds in Fungi, Protozoa, Plants and Vertebrates.- Mechanism of Metabolic Activation of Nitroimidozoles.- Benzene Metabolism R. Snyder.- Mechanisms of Benzene Toxicity.- Hematotoxicity, Leukemogenecity and Carcinogenecity of Chronic Exposure to Benzene.- Epoxide Hydrolase Isoenzymes and Their Individual Contribution to the Control of Toxic Metabolites.- Role of the Weil-Known Basic and Recently Discovered Acidic Glutathione S-Transferases in the Control of Genotoxic Metabolites.- Characterisation and Regulation of UDP-Glucuronosyltransferases.- Molecular Cloning, Expression and Genetic Deficiencies of UDP-Glucuronosyltransferases.- Contributors.
PRODUCT DETAILS
Publisher: Springer (Springer-Verlag New York Inc.)
Publication date: December, 2012
Pages: 508
Weight: 964g
Availability: Available
Subcategories: Biochemistry, Pharmacology
From the same series
Holger Schmid-Schonbein
C. David
Athel Cornish-Bowden
Roy H. Pottier
A Cooper
W. Taylor
Gregory Gregoriadis
Robert A. Samson
A. Pecile
Nikolas Zagris
Peter A.V. Anderson
Allan D. Callow
S.S. Davis
Gregory Gregoriadis
Kalliopi A. Roubelakis-Angelakis
F. Cattabeni
Janice S. Dorman
C. Nicolini
Ruth Bellairs
Curtis C. Travis
David L. Hawksworth
Bengt Samuelsson
Thomas Elbert
Athel Cornish-Bowden
Allan D. Callow
F. Delange
Giorgio M. Innocenti
W.C. McCallum
John Alden
Douglas R.O. Morrison
B. Marin
Brian L. Strom
Gregory Gregoriadis
M.I. Mackness
Erik De Clercq
Wilfred Cote
J. Axelrod
Jacques Dumont
Antonio Borsellino
G. Gregoriadis
Claudio Nicolini
Martino Grandolfo
Antonio Pecile
F. Lamberti
Terry J. Beveridge
Michael E. Maragoudakis
Cesare Sirtori
Curtis Travis
Shimon Gatt
Hans Degn
E.C. Tjamos
Michael E. Maragoudakis
Claudio Nicolini
P. H. Smith
M. Ali
A. Quintanilha
Jose Cunha-Vaz
C Thomas Caskey
J. E. Celis
Alan Kolber
Gurdal N. Alaeddinoglu
R. Bercoff
Stephane Swillens
J. Don Read
H. F. Bradford
Francesco Ghetti
P.M. Mannucci
Suresh C. Srivastava
John S. Axford
Frederic J. Burns
Paul F. Lurquin
Giorgio M. Innocenti
Lester Packer
Filipe Cabello
William F. Dove
F. Berti
Hubert Peeters
Claudio Nicolini
Prakash Chandra
Gregory Gregoriadis
Gregory Gregoriadis
Corrado L. Galli
Erik De Clercq
Demetrios A. Spandidos
Claudio Nicolini
H. Peeters
M. L. Thakur
R. T. Walker
Corraldo Galli
Claudio Nicolini
Robert M. Burton
Hans-Jurg Marthy
R. E. Foreman
Joan H. Argyroudi-Akoyunoglou
Miral Dizdaroglu
Francisco Rodriguez-Valera
Russel J. Reiter
Giulio Milazzo
Constantine Zervos
Arne Valberg
Allan D. Callow
J.Richard Hinchliffe
R.G. Herrmann
Nahum Sonenberg
P.J. Barnes
Franco Celada
Joseph G. Cloud
Gregory Gregoriadis
Gregory Gregoriadis
Sarnoff A. Mednick
Simon D. Shorvon
Oleg Jardetzky
Vincent Torre
J. Martin-Comin
Leo M. Chalupa
Michael E. Maragoudakis
Sarnoff A. Mednick
Gregory Gregoriadis
P. Bagnoli
E.M. Fielden
David B. Allison
Russel J. Reiter
Harry Meinardi
D.J. Galton
Gregory Gregoriadis
Jacques Breton
Richard Bandler
Andrea Boicelli
Wolfram Boucsein
Nuri Akkas
Sadis Matalon
William M. Wardell
D. Karcher
F. Berti
Lucien Ledoux
Barry W. Festoff
Claudio Nicolini
Orio Ciferri
R. Perez-Bercoff
A. Breccia
F. Hillenkamp
Rodolfo Paoletti
Robert W Wissler
R. D. Freeman
L.M.G. Heilmeyer
Ralph Bradshaw
F. Delange
B. Samuelson
G. Galli
Tom Scott
Gregory Gregoriadis
Aldo Rescigno
M.R. Ahuja
Frade Fonnum
Vincent Torre
Miguel A. Merchán
T. Norman Palmer
Gregory Gregoriadis
Robert C. Brown
Upendra K. Pandit
E. Kenneth Weir
H. Hildebrand
Allan D. Callow
M. Paubert-Braquet
Michael E. Maragoudakis
Giuliano Colombetti
Corrado L. Galli
John Stein
Ruth F. Jarrett
Gregory Gregoriadis
Ned H.C. Hwang