(To see other currencies, click on price)
MORE ABOUT THIS BOOK
Main description:
"Biologically Based Methods for Cancer Risk Assessment", an Advanced Research Workshop, (ARW) sponsored by the North Atlantic Treaty Organization (NATO) was held in Corfu, Greece in June, 1989. The intent of the workshop was to survey available pharmacokinetic and pharmacodynamic methods in cancer risk assessment and identify methodological gaps and research needs for biologically based methods in cancer risk assessment. Incorporation of such methods represents one of the most challenging areas for risk assessment. The workshop included an international group of invited experts in the field and provided for a dynamic exchange of ideas and accomplishments. Some of the major topics discussed were: * Inventory of available pharmacokinetic and pharmacodynamic methods for cancer risk assessment. * Identification of methodology gaps and research needs in biologically based methods in cancer risk assessment. * Development of a general framework to guide future cancer risk assessment research. This book is a compilation of the papers presented at the workshop and is intended to provide guidance for future research to reduce uncertainties in the cancer risk assessment process. The primary sponsorship of this ARW by NATO and the advice and cooperation of Dr. C. Sinclair of the Scientific affairs Division are gratefully acknowledged. Acknowledgement is also given to the National Science Foundation for its support. The organization of the ARW and the preparation of this book have required considerable help from many other sources.
Contents:
Research Needs for Biologically Based Risk Assessment.- Biological Bases for Cancer Models.- Multistage Models for Cancer Risk Assessment.- Understanding Multi-Stage Carcinogenesis at the Molecular Level: Notes on Recent Progress.- The Use of Enzyme-Altered Foci for Risk Assessment of Hepatocarcinogens.- Pathogenic Interrelationship of Focal Lesions, Nodules, Adenomas and Carcinomas in the Multistage Evolution of Azaserine-Induced Rat Pancreas Carcinogenesis.- Phenotypic Cellular Changes in Multistage Carcinogenesis.- Interspecies Extrapolation of Pharmacokinetics.- Interspecies Extrapolation.- Comparative Carcinogenesis: Is There a Theoretical Approach to Inter-Species Similarity.- Biological Basis for Interspecies Extrapolations of Halogenated Solvents and of 1,3-Butadiene.- Species-Specific Inhalation Pharmacokinetics of 2-Nitropropane, Methyl Ethyl Ketone, and n-Hexane.- Promotion as a Factor in Carcinogenesis.- Overview of Promotion as a Mechanism in Carcinogenesis.- Hepatocarcinogenesis by Non-Genotoxic Compounds.- The Role of Inhibited Intercellular Communication in Carcinogenesis: Implications for Risk Assessment From Exposure to Chemicals.- Comparative Analyses of the Timing and Magnitude of Genotoxic and Nongenotoxic Cellular Effects in Urinary Bladder Carcinogenesis.- Alterations in Gene Expression in Mouse Hepatocarcinogenesis.- Screening for Carcinogenesis.- Medium-Term Bioassay Models for Environmental Carcinogens - Two - Step Liver and Multi-Organ Carcinogenesis Protocols.- The Use of Aldh Induction as a Carcinogenic Risk Marker in Comparison With Typical in Vitro Mutagenicity System.- Expression of Inducible Cytochrome P-450 mRNAs During Promotion of Expermential Chemical Hepatocarcinogenesis.- An In Vitro Approach for Interspecies Extrapolation Using Animal and Human Airway Epithelial Cell Culture.- Cancer Risk Assessment.- Assement of Low-Exposure Risk from Carcinogens: Implications of the Knudson-Moolgavkar Two-Critical Mutation Theory.- A Biological Data Base for Methylene Chloride Risk Assessment.- Computer Simulation of Chemical Carcinogenesis.- Determination of Carcinogen Exposure by Immunological Techniques.- Risk Estimation for Leukemogenic Drugs.- Contributors.
PRODUCT DETAILS
Publisher: Springer (Springer-Verlag New York Inc.)
Publication date: April, 2013
Pages: 355
Weight: 699g
Availability: Available
Subcategories: Oncology
From the same series
Holger Schmid-Schonbein
C. David
Athel Cornish-Bowden
Roy H. Pottier
A Cooper
W. Taylor
Gregory Gregoriadis
Robert A. Samson
A. Pecile
Nikolas Zagris
Peter A.V. Anderson
Allan D. Callow
S.S. Davis
Gregory Gregoriadis
Kalliopi A. Roubelakis-Angelakis
F. Cattabeni
Janice S. Dorman
C. Nicolini
Ruth Bellairs
Curtis C. Travis
David L. Hawksworth
Bengt Samuelsson
Thomas Elbert
Athel Cornish-Bowden
Allan D. Callow
F. Delange
Giorgio M. Innocenti
W.C. McCallum
John Alden
Douglas R.O. Morrison
B. Marin
Brian L. Strom
Gregory Gregoriadis
M.I. Mackness
Erik De Clercq
Wilfred Cote
J. Axelrod
Jacques Dumont
Antonio Borsellino
G. Gregoriadis
Claudio Nicolini
Martino Grandolfo
Antonio Pecile
F. Lamberti
Terry J. Beveridge
Michael E. Maragoudakis
Cesare Sirtori
Shimon Gatt
Hans Degn
E.C. Tjamos
Michael E. Maragoudakis
Claudio Nicolini
P. H. Smith
M. Ali
A. Quintanilha
Jose Cunha-Vaz
C Thomas Caskey
J. E. Celis
Alan Kolber
Gurdal N. Alaeddinoglu
R. Bercoff
Stephane Swillens
J. Don Read
H. F. Bradford
Francesco Ghetti
P.M. Mannucci
Suresh C. Srivastava
John S. Axford
Frederic J. Burns
Paul F. Lurquin
Giorgio M. Innocenti
Lester Packer
Filipe Cabello
William F. Dove
F. Berti
Hubert Peeters
Claudio Nicolini
Prakash Chandra
Gregory Gregoriadis
Gregory Gregoriadis
Corrado L. Galli
Erik De Clercq
Demetrios A. Spandidos
Claudio Nicolini
H. Peeters
M. L. Thakur
R. T. Walker
Corraldo Galli
Claudio Nicolini
Robert M. Burton
Hans-Jurg Marthy
R. E. Foreman
Joan H. Argyroudi-Akoyunoglou
Miral Dizdaroglu
Francisco Rodriguez-Valera
Russel J. Reiter
Giulio Milazzo
Constantine Zervos
Arne Valberg
Allan D. Callow
J.Richard Hinchliffe
R.G. Herrmann
Nahum Sonenberg
P.J. Barnes
Franco Celada
Joseph G. Cloud
Gregory Gregoriadis
Gregory Gregoriadis
Sarnoff A. Mednick
Simon D. Shorvon
Oleg Jardetzky
Vincent Torre
J. Martin-Comin
Leo M. Chalupa
Michael E. Maragoudakis
Sarnoff A. Mednick
Gregory Gregoriadis
P. Bagnoli
E.M. Fielden
David B. Allison
Russel J. Reiter
Harry Meinardi
D.J. Galton
Gregory Gregoriadis
Jacques Breton
Richard Bandler
Andrea Boicelli
Wolfram Boucsein
Nuri Akkas
Sadis Matalon
William M. Wardell
D. Karcher
F. Berti
Lucien Ledoux
Barry W. Festoff
Claudio Nicolini
Orio Ciferri
R. Perez-Bercoff
A. Breccia
F. Hillenkamp
Rodolfo Paoletti
Robert W Wissler
R. D. Freeman
L.M.G. Heilmeyer
Ralph Bradshaw
F. Delange
B. Samuelson
G. Galli
Tom Scott
Gregory Gregoriadis
Aldo Rescigno
M.R. Ahuja
Frade Fonnum
Vincent Torre
Miguel A. Merchán
T. Norman Palmer
Gregory Gregoriadis
Robert C. Brown
Upendra K. Pandit
E. Kenneth Weir
H. Hildebrand
Allan D. Callow
M. Paubert-Braquet
Michael E. Maragoudakis
Giuliano Colombetti
Corrado L. Galli
John Stein
Ruth F. Jarrett
Gregory Gregoriadis
Ned H.C. Hwang