(To see other currencies, click on price)
MORE ABOUT THIS BOOK
Main description:
During October 18-30, 1981, the second course of the International School of Pure and Applied Biostructure, a NATO Advanced Study Institute, was held at the Ettore Majorana Center for Scientific Culture in Erice, Italy, co-sponsored by the International Union Against Cancer, the Italian League Against Cancer, the Italian Ministry of Public Education, the Italian Ministry of Scientific and Technological Research, the North Atlantic Treaty Organization, the Italian National Research Council, the Sicilian Regional Government and two pharmaceutical Companies (Zambeletti and Farmitalia). The subject of the course was "Chemical Carcino genesis" with participants selected world-wide from 18 different countries. It is now eminently clear that.the bulk of human cancers are related to one of several types of environmental exposure. Of the environmental hazards, chemicals are among the best characterized carcinogens. However, how chemicals induce cancer is still poorly understood. Because of the magnitude of the problem and the ob vious need for a much more critical scientific analysis of the process by which cancer is induced (carcinogenesis), it was highly desirable to expose a greater number of scientists with varying background to some of the latest thinking in chemical carcino genesis. The course had this as its major objective and the re sulting book does reflect it.
Contents:
Section I: Chemicals as Carcinogens.- Chemical Carcinogenesis by Polycyclic Aromatic Hydrocarbons.- N-Substituted Aromatic Compounds.- Metabolic Epoxidation of Aflatoxin B1 and Its Metabolites: Patterns of DNA Adduct Formation and Removal in Relation to Biological Effects.- The Problematic Use of Chemical Class Controls in Absence of Information on the Underlying Mechanism.- Discussion.- Section II: DNA Adducts.- DNA Lesions: Nature and Genesis.- DNA Alkaline Elution: Physical Basis of the Elution Process and Validation of this Method as a Screeing Procedure to Identify Chemical Carcinogens.- DNA Fragmentation: Its Predictivity as a Short Term Test.- Measurement of Viscous and Elastic Components of Native DNA Fiber Following Carcinogen Administration.- Initiation of Experimental Liver Carcinogenesis by Chemicals: Are the Carcinogen Altered Hepatocytes Stimulated to Grow into Foci by Different Selection Procedures Identical?.- Influence of DNA Conformation on DNA Methylation and the Direct Binding of N-Methyl-N-Nitroso-N1-Nitro-Guanidine.- Genotoxic Effects of Drugs: Experimental Findings Concerning Some Chemical Families of Therapeutic Relevance.- Discussion.- Section III: Chemicals as Promotors.- Phenobarbital and Other Liver Tumor Promotors.- Molecular Mechanisms of Multistage Carcinogenesis.- Alterations of Liver Architecture in Mice Treated with Anabolic Androgens and Diethylnitrosamine.- Discussion.- Section IV: Carcinogenesis as Multistep Process.- Some Critical Consideration Concerning the Sequential Analysis of Carcinogenesis with Chemicals.- Benign and Malignant Tumor Induction in Mouse Skin.- Progress in the Study of In Vitro Neoplastic Transformation.- Pulse-Carcinogenesis by Ethylnitrosourea in the Developing Rat Nervous System: Molecular and Cellular Mechanisms.- Chromatin, Nuclei and Water: Alterations and Mechanisms for Chemically-Induced Carcinogenesic.- The Cytoskeleton: An Intermediate in the Expression of the Transformed Phenotype in Malignant Cells.- Discussion.- List of Participants.- Contributor Index.
PRODUCT DETAILS
Publisher: Springer (Springer-Verlag New York Inc.)
Publication date: November, 2012
Pages: 492
Weight: 972g
Availability: Available
Subcategories: Veterinary Medicine
From the same series
Holger Schmid-Schonbein
C. David
Athel Cornish-Bowden
Roy H. Pottier
A Cooper
W. Taylor
Gregory Gregoriadis
Robert A. Samson
A. Pecile
Nikolas Zagris
Peter A.V. Anderson
Allan D. Callow
S.S. Davis
Gregory Gregoriadis
Kalliopi A. Roubelakis-Angelakis
F. Cattabeni
Janice S. Dorman
C. Nicolini
Ruth Bellairs
Curtis C. Travis
David L. Hawksworth
Bengt Samuelsson
Thomas Elbert
Athel Cornish-Bowden
Allan D. Callow
F. Delange
Giorgio M. Innocenti
W.C. McCallum
John Alden
Douglas R.O. Morrison
B. Marin
Brian L. Strom
Gregory Gregoriadis
M.I. Mackness
Erik De Clercq
Wilfred Cote
J. Axelrod
Jacques Dumont
Antonio Borsellino
G. Gregoriadis
Claudio Nicolini
Martino Grandolfo
Antonio Pecile
F. Lamberti
Terry J. Beveridge
Michael E. Maragoudakis
Cesare Sirtori
Curtis Travis
Shimon Gatt
Hans Degn
E.C. Tjamos
Michael E. Maragoudakis
Claudio Nicolini
P. H. Smith
M. Ali
A. Quintanilha
Jose Cunha-Vaz
C Thomas Caskey
J. E. Celis
Alan Kolber
Gurdal N. Alaeddinoglu
R. Bercoff
Stephane Swillens
J. Don Read
H. F. Bradford
Francesco Ghetti
P.M. Mannucci
Suresh C. Srivastava
John S. Axford
Frederic J. Burns
Paul F. Lurquin
Giorgio M. Innocenti
Lester Packer
Filipe Cabello
William F. Dove
F. Berti
Hubert Peeters
Claudio Nicolini
Prakash Chandra
Gregory Gregoriadis
Gregory Gregoriadis
Corrado L. Galli
Erik De Clercq
Demetrios A. Spandidos
H. Peeters
M. L. Thakur
R. T. Walker
Corraldo Galli
Claudio Nicolini
Robert M. Burton
Hans-Jurg Marthy
R. E. Foreman
Joan H. Argyroudi-Akoyunoglou
Miral Dizdaroglu
Francisco Rodriguez-Valera
Russel J. Reiter
Giulio Milazzo
Constantine Zervos
Arne Valberg
Allan D. Callow
J.Richard Hinchliffe
R.G. Herrmann
Nahum Sonenberg
P.J. Barnes
Franco Celada
Joseph G. Cloud
Gregory Gregoriadis
Gregory Gregoriadis
Sarnoff A. Mednick
Simon D. Shorvon
Oleg Jardetzky
Vincent Torre
J. Martin-Comin
Leo M. Chalupa
Michael E. Maragoudakis
Sarnoff A. Mednick
Gregory Gregoriadis
P. Bagnoli
E.M. Fielden
David B. Allison
Russel J. Reiter
Harry Meinardi
D.J. Galton
Gregory Gregoriadis
Jacques Breton
Richard Bandler
Andrea Boicelli
Wolfram Boucsein
Nuri Akkas
Sadis Matalon
William M. Wardell
D. Karcher
F. Berti
Lucien Ledoux
Barry W. Festoff
Claudio Nicolini
Orio Ciferri
R. Perez-Bercoff
A. Breccia
F. Hillenkamp
Rodolfo Paoletti
Robert W Wissler
R. D. Freeman
L.M.G. Heilmeyer
Ralph Bradshaw
F. Delange
B. Samuelson
G. Galli
Tom Scott
Gregory Gregoriadis
Aldo Rescigno
M.R. Ahuja
Frade Fonnum
Vincent Torre
Miguel A. Merchán
T. Norman Palmer
Gregory Gregoriadis
Robert C. Brown
Upendra K. Pandit
E. Kenneth Weir
H. Hildebrand
Allan D. Callow
M. Paubert-Braquet
Michael E. Maragoudakis
Giuliano Colombetti
Corrado L. Galli
John Stein
Ruth F. Jarrett
Gregory Gregoriadis
Ned H.C. Hwang