In this volume a comprehensive review of membrane proteins
that regulate complement and perforin-mediated cytolysis is
presented. A detailed analysisis provided of the
biochemical, molecular, and functional features of these
proteins; the glycosyl phosphatidylinositol linked
proteins are covered, with emphasis placed on the functional
importance of this type of membrane anchor. Further chapters
include reviews of the effects of complement activation on
cells that are metabolically active, and of the regulation
of cell killing by cytotoxic lymphocytes, considering the
similarities and disparities between the complement and
perforin systems. The therapeutic use of recombinant CR1
for immune-mediated pathophysiological processes is
discussed in a separate section.
List of Contents.- Regulation of Complement by Membrane Proteins: An Overview.- Decay Accelerating Factor (CD55).- Complement Receptor Type 1.- Membrane Cofactor Protein.- Membrane Inhibitor of Reactive Lysis.- Homologous Restriction Factor.- The Effects of Complement Activation on Platelets.- Effects of the Membrane Attack Complex of Complement on Nucleated Cells.- Glycosyl-Phosphatidylinositol Anchoring of Membrane Proteins.- Paroxysmal Nocturnal Hemoglobinuria.- Perforin-Structure, Function, and Regulation.