This volume provides a set of reviews dedicated to the biology of Interleukin (IL)-10. It includes chapters on its importance for maintaining immune homeostasis in humans, its role in intestinal immunity and its functions during viral and bacterial infections. In addition, it presents reviews on the mechanisms linking innate microbial recognition to the production of IL-10 and on how IL-10 recognition by its receptor functions. The roles of T and B cells as relevant sources of IL-10 are also discussed, with an emphasis on the clinical opportunities offered by IL-10-producing Tr1 cells for the suppression of unwanted immunity. Finally, the functions of other cytokines of the IL-10 family are presented. Collectively, these articles provide a comprehensive overview of our current knowledge on one of the most important anti-inflammatory cytokines known to date.
Presents an in-depth and global analysis of how IL-10 contributes to immunity
Offers a set of reviews dedicated to the biology of IL-10
Provides a comprehensive overview on one of the most important anti-inflammatory cytokines
IL-10 in humans: lessons from the gut, IL-10/IL-10 receptor deficiencies, and IL-10 polymorphisms.
Karin R. Engelhardt and Bodo Grimbacher
Control of intestinal inflammation by interleukin-10.
Abhisake Kole and Kevin J. Maloy
Tr1 cells and the counter-regulation of immunity: natural mechanisms and therapeutic applications.
Maria Grazia Roncarolo, Silvia Gregori, Rosa Bacchetta and Manuela Battaglia.
Interleukin-10-producing B cells and the regulation of immunity.
Ellen Hilgenberg, Ping Shen, Van Duc Dang, Stefanie Ries, Imme Sakwa and Simon Fillatreau.
Pathogen Manipulation of cIL-10 Signaling Pathways: Opportunities for Vaccine Development?
Meghan K. Eberhardt and Peter A. Barry
IL-10: achieving balance during persistent viral infection.
Cherie T. Ng and Michael B.A. Oldstone
The role of microRNAs in the control and mechanism of action of IL-10.
Susan R. Quinn, Luke A. O’Neill
The regulation of IL-10 expression.
Leona Gabryšová, Ashleigh Howes, Margarida Saraiva and Anne O’Garra
The Molecular Basis of IL-10 Function: From Receptor Structure to the Onset of Signaling.
Mark R. Walter
Role of IL-22 in microbial host defense
Celine Eidenschenk, Sascha Rutz, Oliver Liesenfeld, Wenjun Ouyang