Although upstaged by the tragic appearance of the human immunodeficiency virus, herpes simplex viruses (HSV) types 1 and 2 continue to be major human pathogens against which we lack acceptable vaccines or other means of immunological control. The virus is large and complex, coding for 70 or more proteins. Although many mysteries remain to be unraveled, our knowledge base regarding genomic organization, gene expression and regulation, pathogenesis, and immune recog nition of component parts is quite considerable. Indeed, meet ings devoted entirely to herpesviruses are conspicuous by their frequency and excellent, yet sometimes exclusive, attendance. The purpose of this volume is to compile in a single book a series of reviews by leading investigators that deal with various aspects of virus-host interactions and which hopefully will pro vide clues as to how to best manage HSV from an immunobio logical perspective. Ultimately, one anticipates that a full under standing of virus-host interaction will lead to strategies useful for the prevention and control of HSV. The state of current progress with conventional vaccines is presented, as is a chapter on intracellular immunization. This latter novel approach to virus infections comes at approximately the bicentenary of Jenner's introduction of a successful conventional immunization strategy.
Regulation of Herpes Simplex Virus Type 1 Gene Expression.- Pathogenesis of Herpes Simplex Virus Infection and Animal Models for Its Study.- The Role of Immune Mechanisms in Control of Herpes Simplex Virus Infection of the Peripheral Nervous System.- The Role of T Cell Immunity in Control of Herpes Simplex Virus.- The Role of Antibody in Herpes Simplex Virus Infection in Humans.- Macrophages and Other Nonspecific Defenses: Role in Modulating Resistance Against Herpes Simplex Virus.- The Role of Herpes Simplex Virus Glycoproteins in Immune Evasion.- Immunopathology of Herpes Simplex Virus Infections.- Contemporary Approaches to Vaccination Against Herpes Simplex Virus.- Controlling Herpes Simplex Virus Infections: is Intracellular Immunization the Way of the Future?.