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Epigenetic Regulation of Lymphocyte Development
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Main description:

The studies described in this volume serve as a starting point to familiarize one self with the multifarious differences in epigenetic designs that orchestrate the progression of developing blood cells. They also may serve as a general paradigm for the mechanisms that underpin the control of eukaryotic gene expression. 


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Back cover:

Previous observations, generated by many in the field, have provided a first glimpse into the epigenetic mechanisms that underpin lymphocyte and myeloid development. We are only now beginning to merge the multitude of observations into a common framework. At the same time it has become more difficult for the individual mind to comprehend more than a tiny focused fraction of it. The studies described in this volume serve as a starting point to familiarize one self with the multifarious differences in epigenetic designs that orchestrate the progression of developing blood cells. They also may serve as a general paradigm for the mechanisms that underpin the control of eukaryotic gene expression.


Contents:

Preface.- Roles of lineage-determining transcription factors in establishing open chromatin – lessons from high-throughput studies.- B Lymphocyte Lineage Specification, Commitment and Epigenetic Control of Transcription by Early B Cell Factor 1.- Epigenetic features that regulate IgH locus recombination and expression.- Local and global epigenetic regulation of V(D)J recombination.- Genetic and Epigenetic Regulation of TCRbeta Gene Assembly.- T-cell identity and epigenetic memory.- Encoding stability versus flexibility:  Lessons learned from examining epigenetics in T helper cell differentiation.- The epigenetic landscape of lineage choice: lessons from the heritability of Cd4 and Cd8 expression.-  Subject Index


PRODUCT DETAILS

ISBN-13: 9783642241024
Publisher: Springer (Springer Berlin Heidelberg)
Publication date: January, 2012
Pages: 201
Weight: 473g
Availability: POD
Subcategories: Genetics, Immunology
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