BOOKS BY CATEGORY
Your Account
Current Topics in Microbiology and Immunology
Ergebnisse der Mikrobiologie und Immunitatsforschung Volume 59
Price
Quantity
€145.92
(To see other currencies, click on price)
Paperback / softback
Add to basket  

MORE ABOUT THIS BOOK

Main description:

Influenza continues to be one of the major epidemic diseases of man and is, in fact, his only remaining pandemic disease (BEVERIDGE, 1969). This is largely because influenza virus undergoes extreme antigenic variation, the mechanism of which is still poorly understood. Two kinds of antigenic variation occur in influenza viruses, antigenic drift and major antigenic shifts; both involve chan ges in the hemagglutinin and neuraminidase antigens on the surface of the virus. Antigenic drift, which involves gradual changes in the surface antigens of influenza virus, is thought to result from the selection by an immune popula tion of mutant virus particles with altered antigenic determinants. These mutants therefore possess a growth advantage in the presence of antibody (FRAN CIS and MAASSAB, 1965; ARCHETTI and HORSFALL, 1950; HAMRE et aI., 1958). It has been shown that antigenic mutants isolated in vitro by selection with antibody have changes in amino acid sequence in the polypeptides of the hem agglutinin subunits (LAVER and WEBSTER, 1968) and it is likely that antigenic drift in the neuraminidase occurs by the same mechanism.


Contents:

Paramyxovirus Replication.- Viral and Bacterial Neuraminidases.- On the Origin of Pandemic Influenza Viruses.- Physiological and Genetic Studies of Polyoma Virus.- Antigen Recognition by B and T Lymphocytes.- Genetic Control of Immune Responses.- Author Index.


PRODUCT DETAILS

ISBN-13: 9783642654466
Publisher: Springer (Springer-Verlag Berlin and Heidelberg GmbH & Co. K)
Publication date: November, 2011
Pages: None
Weight: 462g
Availability: Available
Subcategories: General Issues, General Practice, Immunology
Related books
From the same series

CUSTOMER REVIEWS

Average Rating