Main description:

The second volume of the Biomedical translational research discusses advancements in biomedical research for understanding the pathophysiology of various diseases towards improving diagnosis and treatment. It presents the integration of molecular-based technologies, clinical genomics, and medical informatics to improve diagnostic and treatment strategies. Further, the book reviews molecular genomics approaches for diagnosis and managing tuberculosis. It also covers the innovative strategies for cancer treatment through targeting metabolic pathways, tumor microenvironment, cancer stem cells, and immune cells. It also illuminates novel strategies for heart failure diagnosis and therapeutic approaches for the treatment of heart failure. It discusses improvements in translational research for discovery of new diagnostic tests, identifying novel biomarkers and drugable targets, and predicting optimal treatments based on understanding the underlying molecular basis of the disease. Lastly, it reviews the preclinical models of restenosis and their application and limitation in the evaluation of device-based interventional technologies for the treatment of coronary artery diseases.

Contents:

Application of clinical genomics in diagnosis and disease treatment
Exosomes as novel biomarkers of disease
Membrane Lipids: Implication for Diseases and Membrane Trafficking
Human natural killer cells and their cytotoxic capacity
Molecular genomic approaches for diagnosing and managing tuberculosis
Exploring the origin of cancer with stem cell biology
Therapeutic potential of skin stem cells in vitiligo
Clinical applications of cancer stem cells
Immuno therapeutic approaches for cancer treatment
Future of uro-oncology
Prostate Cancer: Circadian Gene Regulated Malignancy
Role of adenosine pathway in cancer
Immune modulation and VEGF
Modulating tumour microenvironment in the treatment of cancer
The endosymbiont role of mitochondria in cancer progression and therapy
Interplay of cancer associated fibroblasts and tumour associated macrophages in metastasis
Chimeric antigen receptor therapy : A cutting edge therapy for multiple myeloma
The future therapies for heart failure
Futuristic experimental studies on heart failure and ischemic heart diseases
AGE-PAGE Stress in the pathophysiology of atherosclerosis and its treatment
Genetics of Left Ventricular Dysfunction in Coronary Artery Disease
Gene editing in liver disease
Interrupting crystal to calculus conversion : The future of renal stone research
Preclinical models of intimal hyperplastic and restenosis for the development of novel therapies
Nanoparticles in counteracting multidrug resistant bacterial

Rapid eye movement sleep and dream sleep