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MORE ABOUT THIS BOOK
Main description:
The preparation of Aging, Immunity, and Infection has been a "labor of labor. " When we began, there existed a huge literature-but manage able, we thought, given our years of experience in the area often referred to as immunogerontology. However, in the time that we have been at work, the new relevant literature has increased at a prodigious rate. The more we read and tried to assimilate, the farther we fell behind. In order to have any hope of completing a book on this rapidly evolving topic, we have been forced to become increasingly selective in covering new and re cent publications. We dare to hope that many read ers will find the book useful and only a few will dweIl on the inevitable inadequacies. We consider the book a work in progress, and welcome suggestions for future editions. Five chapters cover several aspects of infection and the decline of immunity with age. The first chapter "Human Aging: Present and Future," is devoted to demographics and theories of senescence. Chap ter 2 outlines the gradual breakdown of resistance to infection in the aged individual. Chapters 3 and 4 cover changes in innate and acquired immunity. The final chapter, "Nutrition, Longevity, and Integrity of the Immune System," discusses such provocative ideas as life-span exten sion and nutritional intervention for the delay of immunosenescence.
Contents:
Human Aging: Present and Future
Demographics
Infectious Diseases of the Aging
Limits on Life Expectancy and Future Prospects
Theories of Senescence
Chapter Summary
References
Aging and Altered Resistance to Infection
Relatively Common Bacterial Infections of Aging Humans
Selected Examples of Age-Associated Susceptibility to Bacterial Infections
Bacterial Interactions with Mucosal Surfaces
Antibiotic Resistance and Bacterial Variation
Viral Infections in Aging Humans
Protozoan Parasites in Aging Subjects.
Fungal Infections in Aging Subjects
Chapter Summary
References
Senescence of Natural/Innate Resistance to Infection
Pattern Recognizing Receptors of Innate Immunity
Phagocytic Cells: Monocytes/Macrophages
Microbial Evasion of Phagocytic Destruction
Age-Related Changes in Macrophages
Phagocytic Cells: Neutrophils
Natural Killer/Lymphokine-Activated Killer Cells
Chapter Summary
References
Aging of Adaptive/Acquired Immunity
Aging of the Thymus and Thymus-Derived (T) Cells
The Functions and Diversity of Peripheral T Cells
Summary: Known and Cognizable Effects of Aging T Cells
Differentiation, Functions, and Aging of B Cells
Chapter Summary
References
Nutrition, Longevity, and Integrity of the Immune System
RCI-Mediated Delay of Immunosenescence
How Does RCI Promote Life-Span Extension?
Dietary Restriction vs Malnutrition
References
Epilogue
Index
PRODUCT DETAILS
Publisher: Springer (Humana Press Inc.)
Publication date: September, 2012
Pages: 241
Weight: 374g
Availability: Available
Subcategories: Diseases and Disorders, Geriatrics, Infectious Diseases
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