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Cytokines and Chemokines in Infectious Diseases Handbook
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Main description:

A comprehensive review of what is known about the role of cytokines and chemokines in a variety of human infectious diseases, including gram-negative and -positive infections, listeriosis, mycobacterial infections, lyme arthritis, pneumonia, fungal infections, HIV, leishmaniasis, and sepsis. The authors demonstrate the different cytokine and chemokine production profiles in response to a wide variety of pathogens and the importance of host genetic factors in determining the type and magnitude of responses to a given microorganism. They also critically evaluate the use of cytokines and anticytokines in the treatment of infectious diseases and show how knowledge of cytokine pleiotropic effects, redundancy, and the complexity of the cytokine network has led to better design and better outcomes in cytokine-based therapies for specific infections.


Contents:

Introduction: Cytokine Biology Relevant to Infectious Diseases
Charles A. Dinarello

I. Cytokines in Infectious Diseases

Leptin: Its Role in Immunomodulation and Susceptibility to Infection
Graham Lord

Cytokine Gene Polymorphism and Host Susceptibility to Infection
Frank Stuber

II. Cytokines in Gram-Negative Infections

Proinflammatory and Anti-Inflammatory Cytokines as Mediators of Gram-Negative Sepsis
Jean-Marc Cavaillon

Host Response to Pathogenic Bacteria at Mucosal Sites
Laurence Arbibe and Philippe Sansonetti

Macrophage Migration Inhibitory Factor as a Cytokine of Innate Immunity
Thierry Calandra

III. Cytokines in Gram-Positive Infections

Cytokine Patterns in Severe Invasive Group A Streptococcal Infections
Anna Norrby-Teglund and Malak Kotb

Superantigens and Bacterial DNA as Cytokine Inducers in Gram-PositiveSepsis
Klaus Heeg

Cytokines and Chemokines in Listeriosis
Michael S. Rolph and Stefan H. E. Kaufmann

IV. Cytokines in Mycobacterial Infections

Regulation of Cytokines and Chemokines Responses in Human Mycobacterium tuberculosis Infection
Zahra Toossi and Jerrold J. Ellner

Cytokines and Chemokines in Protective and Inflammatory Responses to Infection with Nontuberculous Mycobacteria
Stefan Ehlers

Human Interleukin-12-Interferon-g Axis in Protective Immunity to Mycobacteria
Claire Fieschi, Stephanie Dupuis, Capucine Picard, and Jean-Laurent Casanova

Role of Th1 Cytokines in Host Defenses Against Mycobacterium leprae
Elizabeth Pereira Sampaio, Milton Ozorio Moraes, M. Cristina Vidal Pessolani, and Euzenir Nunes Sarno

V. Cytokines in Other Bacterial Infections

Possible Role of Molecular Mimicry in Lyme Arthritis
Abbie L. Meyer and Brigitte T. Huber

Cytokine Responses in Patients withPneumonia
Peter Kragsbjerg and Hans Holmberg

VI. Cytokines in Fungal Infections

Cytokines and the Host Defense Against Aspergillus fumigatus
Emmanuel Roilides, Joanna Filioti, and Cristina Gil-Lamaignere

Cytokines of Innate and Adaptive Immunity to Candida albicans
Luigina Romani

VII. Cytokines in Parasitic Infections

Th1 and Th2 Cytokines in Leishmaniasis
Fabienne Tacchini-Cottier, Genevieve Milon, and Jacques A. Louis

Cytokines in the Regulation of Innate and Adaptive Immunity to Toxoplasma gondii
Ulrike Wille and Christopher A. Hunter

VIII. Cytokines in Viral Infections

Viroceptors: Virus-Encoded Receptors for Cytokines and Chemokines
Grant McFadden

Chemokines and Chemokine Receptors in HIV Infection
Paolo Lusso

Cytokines in Viral Hepatitis
Mala K. Maini and Antonio Bertoletti

IX. Cytokines as Therapeutic Agents in Infectious Diseases

Interferon-g in the Treatment of Infectious Diseases
Steven M. Holland and John I. Gallin

Interleukin-2 for the Treatment of HIV Infection
Guido Poli, Claudio Fortis, Adriano Lazzarin, and Giuseppe Tambussi

Clinical Applications of G-CSF and GM-CSF in the Treatment of Infectious Diseases
Kai Hubel, David C. Dale, Richard K. Root, and W. Conrad Liles

X. Anticytokine-Based Therapy in Treatment of Infectious Diseases

Anticytokine Therapies in Patients with Severe Sepsis and Septic Shock
Pierre-Yves Bochud, Michel P. Glauser, and Thierry Calandra

Intravenous Immunoglobulin Adjunctive Therapy in Patients with Streptococcal Toxic Shock Syndrome and Necrotizing Fasciitis
Anna Norrby-Teglund, Donald E. Low, and Malak Kotb

Index


PRODUCT DETAILS

ISBN-13: 9781617372476
Publisher: Springer (Humana Press Inc.)
Publication date: November, 2010
Pages: 452
Weight: 861g
Availability: Available
Subcategories: Infectious Diseases
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