For decades this virus system has served--and continues to do so--to pioneer investigations on the molecular biology, biochemistry and genetics of mammalian cell systems. This three volume work presents an up-to-date account of recent basic research in one of the most important experimental systems for biochemical, cell biological, genetic, virological and epidemiological investigation in mammalian molecular biology. In the first of the three volumes, we present an overview of adenovirus research. In the second volume, we turn our attention to such topics as DNA replication, recombination and integration and post-trans- criptional control. This, the third volume then looks at transformation and E1A, adenovirus genetics, pathogenesis and gene therapy.
Modulation of Gene Expression by Adenovirus Transformation.- Adenovirus E1A: Transcription Regulation and Alteration of Cell Growth Control.- Regulation of p53-Dependent Apoptosis by E1A and E1B.- Transcriptional Modulation by the Adenovirus E1A Gene.- Regulation of Viral and Cellular Gene Expression by E1A Proteins Encoded by the Oncogenic Adenovirus Type 12.- Transcriptional Regulation of the Adenovirus E1A Gene.- Functional Domains of Adenovirus E1A Oncogenes Which Control Interactions with Effectors of Cellular Immunity.- Assessing the Role of E1A in the Differential Oncogenicity of Group A and Group C Human Adenoviruses.- Regulation of Adenovirus E2 Transcription Unit.- Model Systems for Studying the Effects of Adenovirus E3 Genes on Virulence In Vivo.- Molecular Determinants of Adenovirus Tropism.- Enteric Adenoviruses.- Adenovirus-Augmented, Receptor-Mediated Gene Delivery and Some Solutions to the Common Toxicity Problems.- Gene Therapy Using Adenovirus Vectors.