For decades this virus system has served - and continues to do so - to pioneer investigations on the molecular biology, biochemistry and genetics of mammalian cell systems. This three volume work presents an up-to-date account of recent basic research in one of the most important experimental systems for biochemical, cell biological, genetic, virological, and epidemiological investigations in mammalian molecular biology. In this, the first of the three volumes, an overview of adenovirus research is presented with emphasis on the structure and assembly of adenoviruses, viral infections, and viral gene products. The chapters have been written by an international group of leading experts in their respective fields of interest.
List of Contents.- Adenovirus — An Eternal Archetype.- Adenovirus Structure by X-Ray Crystallography and Electron Microscopy.- Structure of the Receptor Binding Domain of Adenovirus Type 5 Fiber Protein.- Virus Assembly.- Selective Encapsidation of Adenovirus DNA.- Role of Adenovirus Structural Components in the Regulation of Adenovirus Infection.- Nuclear Organization of Replication and Gene Expression in Adenovirus-Infected Cells.- Abortive Adenovirus Infection and Host Range Determinants.- Functional Similarity Between Adenovirus E1B 19-kDa Protein and Proteins Encoded by Bcl-2 Proto-Oncogene and Epstein-Barr Virus BHRF1 Gene.- Adenovirus Fiber.- Transcription of Adenovirus RNA Polymerase III Genes.- Adenovirus Endopeptidase and Its Role in Virus Infection.- E3 Transcription Unit of Adenovirus.