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T Cell Activation by CD1 and Lipid Antigens
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Main description:

There is increasing evidence that the CD1 system has been conserved throughout mammalian evolution and is capable of presenting structurally diverse diacyglycerol, sphingolipid, polyisoprenol and lipopeptide antigens. This volume provides a comprehensive discussion of these basic aspects of CD1 biology and summarizes the most recent research into the role of CD1 in infectious, autoimmune, allergic and neoplastic disease.


Feature:

Presents evidence that the CD1 system has been conserved throughout mammalian evolution


Studies cell systems in context of their immunological functions


Summarizes the most recent research into the role of CD1 in infectious, autoimmune, allergic and neoplastic disease


Back cover:

For decades, T cells were thought to solely respond to protein-derived antigens. However, the discovery of the CD1 antigen presenting system shows how antigen presenting cells can display lipid antigens to T cells. Crystal structures show that CD1 proteins accomplish this function by inserting lipids into a hydrophobic groove on the distal surface of the protein, forming CD1-lipid complexes that act as ligands for T cell receptors. CD1-reactive T cells with conserved (NK T cells) or diverse T cell receptors possess cytokine secretion and other effector mechanisms that influence many aspects of immune response. There is increasing evidence that the CD1 system has been conserved throughout mammalian evolution and is capable of presenting structurally diverse diacyglycerol, sphingolipid, polyisoprenol and lipopeptide antigens. These features of CD1 antigen presentation systems now point to a new and expanded view of the natural function of ab T cells, which involves surveillance of both the protein and lipid components of target cells. Further, cellular systems that were previously considered to have functions in lipid metabolism can now be studied in context of their immunological functions. This volume provides a comprehensive discussion of these basic aspects of CD1 biology and summarizes the most recent research into the role of CD1 in infectious, autoimmune, allergic and neoplastic disease.


Contents:

Section 1 - Molecular Biology.- Chapter 1 - Evolutionary Biology of the CD1.- Chapter 2 - Architecture of CD1 Proteins.- Chapter 3 - Structures and Biology of Self Lipid Antigens.- Chapter 4 - Structures and Functions of Microbial Lipid Antigens.- Section 2 - Cellular Biology.- Chapter 5 - CD1 Expression on Antigen Presenting Cells.- Chapter 6 - Pathways of CD1 and Lipid Antigen Delivery, Trafficking, Processing, Loading and Presentation.- Chapter 7 - TCR-Mediated Recognition of Glycolipid CD1 Complexes.- Chapter 8 - Development and Selection of Va14i NKT Cells.- Section 3 - Disease.- Chapter 9 - CD1-Restricted T Cells in Host Defense to Infectious Diseases.- Chapter 10 - NKT Cells and Autoimmune Diseases: Unraveling the Complexity.- Chapter 11 - iNKT Cells in Allergic Disease.- Chapter 12 - CD1-Restricted T Cells and Tumor Immunity.- Chapter 13 - Harnessing NKT Cells for Therapeutic Applications.- Subject index


PRODUCT DETAILS

ISBN-13: 9783540695103
Publisher: Springer (Springer Berlin Heidelberg)
Publication date: May, 2007
Pages: 356
Availability: Available
Subcategories: Immunology
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